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Wnt9a Gene Detail
Summary
  • Symbol
    Wnt9a
  • Name
    wingless-type MMTV integration site family, member 9A
  • Synonyms
    Wnt14
  • Feature Type
    protein coding gene
  • IDs
    MGI:2446084
    NCBI Gene: 216795
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:59197754-59224378 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2446084
protein coding gene Chr11:59197675-59224378 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018395
protein coding gene Chr11:59134223-59162435 (+)
A/J MGP_AJ_G0018364
protein coding gene Chr11:56870933-56897423 (+)
AKR/J MGP_AKRJ_G0018334
protein coding gene Chr11:58773918-58802400 (+)
BALB/cJ MGP_BALBcJ_G0018335
protein coding gene Chr11:57226244-57252746 (+)
C3H/HeJ MGP_C3HHeJ_G0018148
protein coding gene Chr11:58649136-58675515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018787
protein coding gene Chr11:61005646-61034393 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016433
protein coding gene Chr11:54121903-54148332 (+)
CAST/EiJ MGP_CASTEiJ_G0017705
protein coding gene Chr11:58782815-58845856 (+)
CBA/J MGP_CBAJ_G0018122
protein coding gene Chr11:63676503-63705973 (+)
DBA/2J MGP_DBA2J_G0018231
protein coding gene Chr11:56542979-56569397 (+)
FVB/NJ MGP_FVBNJ_G0018222
protein coding gene Chr11:56192564-56220711 (+)
LP/J MGP_LPJ_G0018304
protein coding gene Chr11:59733264-59759594 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018246
protein coding gene Chr11:64806757-64834675 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018828
protein coding gene Chr11:58798924-58830404 (+)
PWK/PhJ MGP_PWKPhJ_G0017476
protein coding gene Chr11:57127630-57187621 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017268
protein coding gene Chr11:58593151-58655027 (+)
WSB/EiJ MGP_WSBEiJ_G0017756
protein coding gene Chr11:58483681-58513182 (+)



Homology
more
  • Human Ortholog
    WNT9A, Wnt family member 9A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT9A, Wnt family member 9A
  • Synonyms
    WNT14
  • Links
    NCBI Gene ID: 7483
    neXtProt AC: NX_O14904
    UniProt: O14904

  • Chr Location
    1q42.13; chr1:227918656-227947932 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human WNT9A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in neonatal lethality, altered chondrocyte maturation, cranial defects, and skeletal abnormalities including shortened appendicular long bones, partial joint fusions of carpal and tarsal elements, and chondroid metaplasia in synovial and fibrous joints.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000126 Ensembl Gene Model | MGI Sequence Detail 26625 C57BL/6J ±  kb
    transcript ENSMUST00000000128 Ensembl | MGI Sequence Detail 3320 Not Applicable  
    polypeptide ENSMUSP00000000128 Ensembl | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 9
      Primer pair 5
      Other 8

      Microarray probesets 3
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 73
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:341689 Zhang B, et al., KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors. Nat Commun. 2023 Oct 14;14(1):6489

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory