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Lrrc25 Gene Detail
Summary
  • Symbol
    Lrrc25
  • Name
    leucine rich repeat containing 25
  • Synonyms
    Mapa
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445284
    NCBI Gene: 211228
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71068810-71073501 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445284
protein coding gene Chr8:71068805-71074133 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033715
protein coding gene Chr8:70892504-70896549 (+)
A/J MGP_AJ_G0033698
protein coding gene Chr8:68016150-68020201 (+)
AKR/J MGP_AKRJ_G0033623
protein coding gene Chr8:69948652-69952668 (+)
BALB/cJ MGP_BALBcJ_G0033694
protein coding gene Chr8:68248892-68252902 (+)
C3H/HeJ MGP_C3HHeJ_G0033404
protein coding gene Chr8:70598919-70602988 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034211
protein coding gene Chr8:73573646-73579448 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031155
protein coding gene Chr8:62832855-62836746 (+)
CAST/EiJ MGP_CASTEiJ_G0032729
protein coding gene Chr8:70088575-70092566 (+)
CBA/J MGP_CBAJ_G0033382
protein coding gene Chr8:76208940-76212952 (+)
DBA/2J MGP_DBA2J_G0033536
protein coding gene Chr8:67731518-67735530 (+)
FVB/NJ MGP_FVBNJ_G0033477
protein coding gene Chr8:66858312-66863715 (+)
LP/J MGP_LPJ_G0033623
protein coding gene Chr8:70920885-70924898 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033520
protein coding gene Chr8:78876724-78880706 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034229
protein coding gene Chr8:70134805-70140190 (+)
PWK/PhJ MGP_PWKPhJ_G0032437
protein coding gene Chr8:67032403-67036572 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032273
protein coding gene Chr8:69101677-69105379 (+)
WSB/EiJ MGP_WSBEiJ_G0032844
protein coding gene Chr8:70494992-70498959 (+)



Homology
more
  • Human Ortholog
    LRRC25, leucine rich repeat containing 25
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC25, leucine rich repeat containing 25
  • Synonyms
    MAPA
  • Links
    NCBI Gene ID: 126364
    neXtProt AC: NX_Q8N386
    UniProt: Q8N386

  • Chr Location
    19p13.11; chr19:18391137-18397622 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 211228 NCBI Gene Model | MGI Sequence Detail 4692 C57BL/6J ±  kb
    transcript NM_153074 RefSeq | MGI Sequence Detail 1263 C57BL/6  
    polypeptide Q8K1T1 UniProt | EBI | MGI Sequence Detail 297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 1
    References
    more
    • Summaries
      All 25
      Gene Ontology 2
      Phenotypes 7
    • Earliest
      J:80026 Rissoan MC, et al., Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood. 2002 Nov 1;100(9):3295-303
    • Latest
      J:270157 Zhang X, et al., Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-beta1. Biochem Biophys Res Commun. 2018 Nov 17;506(1):137-144

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/28/2024
    MGI 6.13
    The Jackson Laboratory