Cyp4f39 MGI Mouse Gene Detail - MGI:2445210 - cytochrome P450, family 4, subfamily f, polypeptide 39

Symbol

Cyp4f39
Name

cytochrome P450, family 4, subfamily f, polypeptide 39
Synonyms

4732474A20Rik

Feature Type

protein coding gene
IDs

MGI:2445210
NCBI Gene: 320997
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr17:32671697-32712294 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.59 cM
Mapping Data

1 experiment

SNPs within 2kb

1279 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445210	protein coding gene	Chr17:32671670-32712294 (+)
129S1/SvImJ	ENSMUSG00200052023	protein coding gene	Chr17:28346692-28387272 (+)
A/J	ENSMUSG00195054325	protein coding gene	Chr17:29285001-29325569 (+)
AKR/J	ENSMUSG00220050113	protein coding gene	Chr17:28313045-28353609 (+)
BALB/cJ	ENSMUSG00180046153	protein coding gene	Chr17:28620805-28661381 (+)
C3H/HeJ	ENSMUSG00175051823	protein coding gene	Chr17:28194121-28234683 (+)
C57BL/6NJ	ENSMUSG00215052255	protein coding gene	Chr17:28191730-28232340 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021385	protein coding gene	Chr17:28336461-28360688 (+)
CAST/EiJ	ENSTCUG00005045482	protein coding gene	Chr17:29198138-29239821 (+)
CBA/J	ENSMUSG00210047665	protein coding gene	Chr17:28021032-28061599 (+)
DBA/2J	ENSMUSG00185053742	protein coding gene	Chr17:30632716-30673298 (+)
FVB/NJ	ENSMUSG00205049045	protein coding gene	Chr17:28517091-28558604 (+)
JF1/MsJ	ENSUMUG00000017479	protein coding gene	Chr17:29932351-29974377 (+)
LP/J	ENSMUSG00230054126	protein coding gene	Chr17:31745187-31785766 (+)
NOD/ShiLtJ	ENSMUSG00190045986	protein coding gene	Chr17:28143582-28184275 (+)
NZO/HlLtJ	ENSMUSG00225054325	protein coding gene	Chr17:33782180-33822758 (+)
PWK/PhJ	ENSLUMG00010044250	protein coding gene	Chr17:27757602-27799824 (+)
SPRET/EiJ	ENSMSPG00010041969	protein coding gene	Chr17:28887893-28929942 (+)
WSB/EiJ	ENSIUOG00005044978	protein coding gene	Chr17:28910141-28951901 (+)

Human Ortholog

CYP4F22, cytochrome P450 family 4 subfamily F member 22

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP4F22, cytochrome P450 family 4 subfamily F member 22
Synonyms

ARCI5, INLNE, LI3
Links

HGNC:26820

NCBI Gene ID: 126410

UniProt: Q6NT55
Chr Location

19p13.12; chr19:15508477-15552317 (+) GRCh38

MGI Vertebrate Homology

Cyp4f39 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: CYP4F22
Gene Tree

Cyp4f39

Diseases

1 with human CYP4F22 associations

				Human Disease	Mouse Models
				autosomal recessive congenital ichthyosis 5 IDs autosomal recessive congenital ichthyosis 5 DOID:0060714 ICD10CM:Q80.2 OMIM:604777

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit complete neonatal lethality associated with trans-epidermal water loss, persistent periderm, thin lipid lamella, thick corneocytes, and complete loss of acylceramide.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

1
cDNA Data

8
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

42
RefSeq

4
UniProt

4
CCDS

CCDS28618.1

Ensembl

ENSMUSG00000061126 (Evidence)
NCBI Gene

320997

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061126	Ensembl Gene Model \| MGI Sequence Detail	40598	C57BL/6J	± kb
transcript	ENSMUST00000237491	Ensembl \| MGI Sequence Detail	2618	Not Applicable
polypeptide	ENSMUSP00000158442	Ensembl \| MGI Sequence Detail	532	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR050196 Cytochrome P450 Monooxygenases

IPR036396 Cytochrome P450 superfamily

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:366466 Yamaji M, et al., Alteration of epidermal lipid composition as a result of deficiency in the magnesium transporter Nipal4. J Lipid Res. 2024 Apr 29;65(6):100550

TSS for Cyp4f39:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143713	Chr17:32671693-32671705 (+)	2 bp
Tssr143714	Chr17:32671719-32671731 (+)	28 bp
Tssr143715	Chr17:32711127-32711135 (+)	39,434 bp
Tssr143716	Chr17:32711142-32711173 (+)	39,461 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24