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Plpp7 Gene Detail
Summary
  • Symbol
    Plpp7
  • Name
    phospholipid phosphatase 7 (inactive)
  • Synonyms
    D830019K17Rik, NET39, Ppapdc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445183
    NCBI Gene: 227721
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:31985540-32000827 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    443 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445183
 protein coding gene Chr2:31985540-32000832 (+)
129S1/SvImJ ENSMUSG00200050841
 protein coding gene Chr2:28971813-28972330 (+)
A/J ENSMUSG00195047189
 protein coding gene Chr2:29073181-29073698 (+)
AKR/J ENSMUSG00220053273
 protein coding gene Chr2:29191100-29191617 (+)
BALB/cJ ENSMUSG00180053449
 protein coding gene Chr2:29087839-29088356 (+)
C3H/HeJ ENSMUSG00175049163
 protein coding gene Chr2:29054266-29054783 (+)
C57BL/6NJ ENSMUSG00215044928
 protein coding gene Chr2:29119772-29120289 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023423
 protein coding gene Chr2:27974259-27989577 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210015272
 protein coding gene Chr2:29126824-29127341 (+)
DBA/2J ENSMUSG00185047090
 protein coding gene Chr2:28986466-28986983 (+)
FVB/NJ ENSMUSG00205046964
 protein coding gene Chr2:28833154-28833671 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230041674
 protein coding gene Chr2:30907373-30907890 (+)
NOD/ShiLtJ ENSMUSG00190048202
 protein coding gene Chr2:29087627-29088144 (+)
NZO/HlLtJ ENSMUSG00225007073
 protein coding gene Chr2:38664751-38665268 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PLPP7, phospholipid phosphatase 7 (inactive)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLPP7, phospholipid phosphatase 7 (inactive)
  • Synonyms
    C9orf67, NET39, PPAPDC3
  • Links
    NCBI Gene ID: 84814
    UniProt: Q8NBV4

  • Chr Location
    9q34.13; chr9:131289459-131359022 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects metabolism and nuclear envelope and sarcomere structure in muscle cells, leading to muscle weakness, stunted postnatal growth and lethality before weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    23
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227721 NCBI Gene Model | MGI Sequence Detail 15288 C57BL/6J ±  kb
    transcript NM_001355238 RefSeq | MGI Sequence Detail 2073 C57BL/6  
    polypeptide Q91WB2 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000030220 inactive phospholipid phosphatase 7
      (term hierarchy)
    • InterPro Domains
      IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
      IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 3
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:362995 Zhang Y, et al., Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy. J Clin Invest. 2023 Jul 3;133(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory