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Tmem184b Gene Detail
Summary
  • Symbol
    Tmem184b
  • Name
    transmembrane protein 184b
  • Synonyms
    4732495E13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445179
    NCBI Gene: 223693
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79244884-79287503 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1340 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445179
 protein coding gene Chr15:79244884-79287769 (-)
129S1/SvImJ ENSMUSG00200050282
 protein coding gene Chr15:76365926-76374612 (-)
129S1/SvImJ ENSMUSGG00200054958
 protein coding gene Chr15:76358704-76365929 (-)
A/J ENSMUSGG00195055514
 protein coding gene Chr15:76301500-76308731 (-)
A/J ENSMUSG00195046965
 protein coding gene Chr15:76308728-76317447 (-)
AKR/J ENSMUSGG00220054299
 protein coding gene Chr15:76344895-76352126 (-)
AKR/J ENSMUSG00220050890
 protein coding gene Chr15:76352123-76360842 (-)
BALB/cJ ENSMUSGG00180054983
 protein coding gene Chr15:76178483-76185716 (-)
BALB/cJ ENSMUSG00180049448
 protein coding gene Chr15:76185713-76194432 (-)
C3H/HeJ ENSMUSGG00175055153
 protein coding gene Chr15:76489724-76496952 (-)
C3H/HeJ ENSMUSG00175048904
 protein coding gene Chr15:76496949-76505668 (-)
C57BL/6NJ ENSMUSG00215052589
 protein coding gene Chr15:76264547-76273275 (-)
C57BL/6NJ ENSMUSGG00215055820
 protein coding gene Chr15:76257363-76264550 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020013
 protein coding gene Chr15:73360923-73405151 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055073
 protein coding gene Chr15:76264867-76272099 (-)
CBA/J ENSMUSG00210038448
 protein coding gene Chr15:76272096-76280815 (-)
DBA/2J ENSMUSGG00185057944
 protein coding gene Chr15:76274752-76281984 (-)
DBA/2J ENSMUSG00185039615
 protein coding gene Chr15:76281981-76290698 (-)
FVB/NJ ENSMUSG00205025066
 protein coding gene Chr15:76001819-76010536 (-)
FVB/NJ ENSMUSGG00205054643
 protein coding gene Chr15:75994589-76001822 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230051582
 protein coding gene Chr15:79614358-79623042 (-)
LP/J ENSMUSGG00230055882
 protein coding gene Chr15:79607139-79614361 (-)
NOD/ShiLtJ ENSMUSGG00190055109
 protein coding gene Chr15:76284592-76291814 (-)
NOD/ShiLtJ ENSMUSG00190040868
 protein coding gene Chr15:76291811-76300501 (-)
NZO/HlLtJ ENSMUSG00225052124
 protein coding gene Chr15:79944041-79952962 (-)
NZO/HlLtJ ENSMUSGG00225055148
 protein coding gene Chr15:79936814-79944044 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010044486
 protein coding gene Chr15:77732735-77751235 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TMEM184B, transmembrane protein 184B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM184B, transmembrane protein 184B
  • Synonyms
    C22orf5, FM08, HS5O6A, HSPC256, SLC51C2
  • Links
    NCBI Gene ID: 25829
    UniProt: Q9Y519

  • Chr Location
    22q13.1; chr22:38216395-38273805 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele exhibit delayed axon degeneration following peripheral nerve injury, progressive structural abnormalities at neuromuscular synapses, swellings within sensory terminals, sensory-motor dysfunction, and abnormal autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    48
  • cDNA Data
    87
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223693 NCBI Gene Model | MGI Sequence Detail 42620 C57BL/6J ±  kb
    transcript NM_001378998 RefSeq | MGI Sequence Detail 3431 C57BL/6  
    polypeptide Q8BG09 UniProt | EBI | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      cDNA 87

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 37
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory