Clspn MGI Mouse Gene Detail - MGI:2445153

Symbol

Clspn
Name

claspin
Synonyms

C85083, E130314M08Rik

Feature Type

protein coding gene
IDs

MGI:2445153
NCBI Gene: 269582
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:126450728-126487696 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 60.90 cM
Mapping Data

2 experiments

SNPs within 2kb

196 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445153	protein coding gene	Chr4:126450728-126488326 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028783	protein coding gene	Chr4:128247092-128292411 (+)
A/J	MGP_AJ_G0028742	protein coding gene	Chr4:123200349-123238965 (+)
AKR/J	MGP_AKRJ_G0028695	protein coding gene	Chr4:126583136-126619115 (+)
BALB/cJ	MGP_BALBcJ_G0028765	protein coding gene	Chr4:123772630-123809800 (+)
C3H/HeJ	MGP_C3HHeJ_G0028479	protein coding gene	Chr4:126646114-126689011 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029207	protein coding gene	Chr4:133134935-133175567 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026480	protein coding gene	Chr4:116330715-116367366 (+)
CAST/EiJ	MGP_CASTEiJ_G0027912	protein coding gene	Chr4:124767487-124805006 (+)
CBA/J	MGP_CBAJ_G0028445	protein coding gene	Chr4:136345472-136391549 (+)
DBA/2J	MGP_DBA2J_G0028594	protein coding gene	Chr4:123648625-123685816 (+)
FVB/NJ	MGP_FVBNJ_G0028561	protein coding gene	Chr4:122304452-122341294 (+)
LP/J	MGP_LPJ_G0028695	protein coding gene	Chr4:128530968-128569425 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028587	protein coding gene	Chr4:141377057-141417323 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029245	protein coding gene	Chr4:126940599-126979646 (+)
PWK/PhJ	MGP_PWKPhJ_G0027633	protein coding gene	Chr4:120142222-120179924 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027459	protein coding gene	Chr4:122771719-122817057 (+)
WSB/EiJ	MGP_WSBEiJ_G0027992	protein coding gene	Chr4:127055584-127095884 (+)

Human Ortholog

CLSPN, claspin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLSPN, claspin
Links

HGNC:19715

NCBI Gene ID: 63967

neXtProt AC: NX_Q9HAW4

UniProt: Q9HAW4
Chr Location

1p34.3; chr1:35720213-35769978 (-) GRCh38

MGI Vertebrate Homology

Clspn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CLSPN
Gene Tree

Clspn

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Phenotype Summary

27 phenotypes from 2 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Gene trapped

1
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Clspn
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice show complete embryonic lethality during organogenesis. Heterozygous null mice exhibit reduced female fertility, develop lymphoid hyperplasia as they age, and show increased susceptibility to non-alcoholic fatty liver disease, and increased liver damage and tumorigenesis in the DEN model of hepatocellular carcinoma.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

894
Tissues

57
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clspn

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All Sequences

69
RefSeq

16
UniProt

7
CCDS

CCDS18655.1

Ensembl

ENSMUSG00000042489 (Evidence)
NCBI Gene

269582

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042489	Ensembl Gene Model \| MGI Sequence Detail	36969	C57BL/6J	± kb
transcript	ENSMUST00000048391	Ensembl \| MGI Sequence Detail	5027	Not Applicable
polypeptide	ENSMUSP00000045344	Ensembl \| MGI Sequence Detail	1315	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000005608 claspin

(term hierarchy)
InterPro Domains

IPR024146 Claspin

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All nucleic 17

cDNA 14

Primer pair 3

Microarray probesets 5

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MGI:2140694

Summaries

All 44

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 14
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:332163 Madgwick S, et al., Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential. Biochem J. 2022 Oct 14;479(19):2115-2130

TSS for Clspn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39002	Chr4:126450749-126450750 (+)	22 bp
Tssr39003	Chr4:126450756-126450759 (+)	30 bp
Tssr39004	Chr4:126450764-126450785 (+)	47 bp
Tssr39005	Chr4:126450787-126450813 (+)	72 bp
Tssr39006	Chr4:126450832-126450841 (+)	109 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23