Utp14b MGI Mouse Gene Detail - MGI:2445092 - UTP14B small subunit processome component

Symbol

Utp14b
Name

UTP14B small subunit processome component
Synonyms

4932411L21Rik, jsd

Feature Type

protein coding gene
IDs

MGI:2445092
NCBI Gene: 195434
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:78635600-78645305 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 40.84 cM
Mapping Data

5 experiments

SNPs within 2kb

69 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2445092	protein coding gene	Chr1:78635600-78649229 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016202	protein coding gene	Chr1:79400546-79415677 (+)
A/J	MGP_AJ_G0016185	protein coding gene	Chr1:76621257-76634655 (+)
AKR/J	MGP_AKRJ_G0016142	protein coding gene	Chr1:78696094-78709563 (+)
BALB/cJ	MGP_BALBcJ_G0016140	protein coding gene	Chr1:76711261-76724646 (+)
C3H/HeJ	MGP_C3HHeJ_G0015970	protein coding gene	Chr1:79069810-79084630 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016593	protein coding gene	Chr1:82452801-82466275 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014313	protein coding gene	Chr1:72044563-72057859 (+)
CAST/EiJ	MGP_CASTEiJ_G0015555	protein coding gene	Chr1:78454114-78467566 (+)
CBA/J	MGP_CBAJ_G0015944	protein coding gene	Chr1:85168839-85185494 (+)
DBA/2J	MGP_DBA2J_G0016045	protein coding gene	Chr1:75933338-75950189 (+)
FVB/NJ	MGP_FVBNJ_G0016048	protein coding gene	Chr1:75091946-75105425 (+)
LP/J	MGP_LPJ_G0016117	protein coding gene	Chr1:80530017-80546928 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016068	protein coding gene	Chr1:88389016-88403145 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016640	protein coding gene	Chr1:78845123-78859557 (+)
PWK/PhJ	MGP_PWKPhJ_G0015341	protein coding gene	Chr1:75402854-75416330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015119	protein coding gene	Chr1:78173022-78186579 (+)
WSB/EiJ	MGP_WSBEiJ_G0015616	protein coding gene	Chr1:78630111-78643996 (+)

Human Ortholog

UTP14A, UTP14A small subunit processome component

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UTP14A, UTP14A small subunit processome component
Synonyms

dJ537K23.3, NYCO16, SDCCAG16, Utp14
Links

HGNC:10665

NCBI Gene ID: 10813

neXtProt AC: NX_Q9BVJ6

UniProt: Q9BVJ6
Chr Location

Xq26.1; chrX:129906121-129929761 (+) GRCh38

Human Ortholog

UTP14C, UTP14C small subunit processome component
Synonyms

2700066J21Rik, KIAA0266, UTP14B
Links

HGNC:20321

NCBI Gene ID: 9724

neXtProt AC: NX_Q5TAP6

UniProt: Q5TAP6
Chr Location

13q14.3; chr13:52024691-52033600 (+) GRCh38

MGI Vertebrate Homology

Utp14b stringent orthology
2 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: UTP14A, UTP14C
Gene Tree

Utp14b

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

2 involving Utp14b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous males are sterile with spermatogonial arrest and elevated intratesticular testosterone levels.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

8
UniProt

3
CCDS

CCDS15086.1

Ensembl

ENSMUSG00000079470 (Evidence)
NCBI Gene

195434

			Length	Strain/Species	Flank
genomic	195434	NCBI Gene Model \| MGI Sequence Detail	9706	C57BL/6J	± kb
transcript	NM_001136226	RefSeq \| MGI Sequence Detail	3702	ZRU/MplStud
polypeptide	Q6EJB6	UniProt \| EBI \| MGI Sequence Detail	756	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017229 U3 small nucleolar RNA-associated protein 14 B

(term hierarchy)
InterPro Domains

IPR006709 Small-subunit processome, Utp14

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All nucleic 7

cDNA 7

Microarray probesets 1

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MGD-MRK-11533, MGI:96642

Summaries

All 54

Gene Ontology 5

Phenotypes 34
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:229199 Song HW, et al., shRNA off-target effects in vivo: impaired endogenous siRNA expression and spermatogenic defects. PLoS One. 2015;10(3):e0118549

TSS for Utp14b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7581	Chr1:78635573-78635585 (+)	-21 bp
Tssr7582	Chr1:78635591-78635606 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23