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Dync2i1 Gene Detail
Summary
  • Symbol
    Dync2i1
  • Name
    dynein 2 intermediate chain 1
  • Synonyms
    D430033N04Rik, Dync2l1, Wdr60
  • Feature Type
    protein coding gene
  • IDs
    MGI:2445085
    NCBI Gene: 217935
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:116169882-116226642 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    642 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2445085
 protein coding gene Chr12:116169881-116226665 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020180
 protein coding gene Chr12:119068776-119121669 (-)
A/J MGP_AJ_G0020136
 protein coding gene Chr12:114720297-114773759 (-)
AKR/J MGP_AKRJ_G0020111
 protein coding gene Chr12:118198104-118255106 (-)
BALB/cJ MGP_BALBcJ_G0020119
 protein coding gene Chr12:115143206-115197112 (-)
C3H/HeJ MGP_C3HHeJ_G0019923
 protein coding gene Chr12:118453540-118514426 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020566
 protein coding gene Chr12:122824580-122881053 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018178
 protein coding gene Chr12:110417007-110473119 (-)
CAST/EiJ MGP_CASTEiJ_G0019463
 protein coding gene Chr12:112308178-112366667 (-)
CBA/J MGP_CBAJ_G0019890
 protein coding gene Chr12:127694321-127756579 (-)
DBA/2J MGP_DBA2J_G0020007
 protein coding gene Chr12:114081894-114135044 (-)
FVB/NJ MGP_FVBNJ_G0019992
 protein coding gene Chr12:112769972-112824394 (-)
LP/J MGP_LPJ_G0020081
 protein coding gene Chr12:119100773-119163338 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020028
 protein coding gene Chr12:131003125-131061273 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020595
 protein coding gene Chr12:117374033-117426853 (-)
PWK/PhJ MGP_PWKPhJ_G0019225
 protein coding gene Chr12:108830545-108888732 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019030
 protein coding gene Chr12:110297348-110358007 (-)
WSB/EiJ MGP_WSBEiJ_G0019521
 protein coding gene Chr12:118320812-118376123 (-)



Homology
more
  • Human Ortholog
    DYNC2I1, dynein 2 intermediate chain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNC2I1, dynein 2 intermediate chain 1
  • Synonyms
    CFAP163, DIC6, FAP163, SRPS6, SRTD8, WDR60
  • Links
    NCBI Gene ID: 55112
    neXtProt AC: NX_Q8WVS4
    UniProt: Q8WVS4

  • Chr Location
    7q36.3; chr7:158839245-158958698 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DYNC2I1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality during organogenesis with abnormal head development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    4
  • cDNA Data
    30
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042050 Ensembl Gene Model | MGI Sequence Detail 56761 C57BL/6J ±  kb
    transcript ENSMUST00000039349 Ensembl | MGI Sequence Detail 3721 Not Applicable  
    polypeptide ENSMUSP00000047334 Ensembl | MGI Sequence Detail 999 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:335806 Yan L, et al., Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos. Front Cell Dev Biol. 2023;11:1084245
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory