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Mical2 Gene Detail
Summary
  • Symbol
    Mical2
  • Name
    microtubule associated monooxygenase, calponin and LIM domain containing 2
  • Synonyms
    4921517J23Rik, 5330438E18Rik, Ebitein1, Micalcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444947
    NCBI Gene: 320878
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:111825063-112012313 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 58.75 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5542 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444947
 protein coding gene Chr7:111825032-112012313 (+)
129S1/SvImJ ENSMUSG00200027232
 protein coding gene Chr7:98412692-98554643 (+)
A/J ENSMUSG00195031827
 protein coding gene Chr7:102916292-103058883 (+)
AKR/J ENSMUSG00220033939
 protein coding gene Chr7:96319234-96461824 (+)
BALB/cJ ENSMUSG00180043223
 protein coding gene Chr7:99584384-99726964 (+)
C3H/HeJ ENSMUSG00175044189
 protein coding gene Chr7:100220222-100362177 (+)
C57BL/6NJ ENSMUSG00215049098
 protein coding gene Chr7:99527353-99670349 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030334
 protein coding gene Chr7:114506102-114633659 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210039923
 protein coding gene Chr7:100047192-100189745 (+)
DBA/2J ENSMUSG00185020567
 protein coding gene Chr7:104397351-104539901 (+)
FVB/NJ ENSMUSG00205038455
 protein coding gene Chr7:100010187-100152745 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230045079
 protein coding gene Chr7:110498378-110640921 (+)
NOD/ShiLtJ ENSMUSG00190045043
 protein coding gene Chr7:100208768-100350717 (+)
NZO/HlLtJ ENSMUSG00225016998
 protein coding gene Chr7:108747277-108889256 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MICAL2, microtubule associated monooxygenase, calponin and LIM domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MICAL2, microtubule associated monooxygenase, calponin and LIM domain containing 2
  • Synonyms
    Ebitein1, MICAL-2, MICAL2PV1, MICAL2PV2, mical-cL, MICALCL
  • Links
    NCBI Gene ID: 9645
    UniProt: O94851

  • Chr Location
    11p15.3; chr11:12094008-12362140 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    606
  • Tissues
    4
  • cDNA Data
    26
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038244 Ensembl Gene Model | MGI Sequence Detail 187251 C57BL/6J ±  kb
    transcript ENSMUST00000037991 Ensembl | MGI Sequence Detail 3352 Not Applicable  
    polypeptide ENSMUSP00000047639 Ensembl | MGI Sequence Detail 1102 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918127
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
    • Latest
      J:381104 Wiszniak S, et al., Neural crest cell-derived DKK1 and NEDD4 modulate Wnt signalling in the second heart field to orchestrate outflow tract development. Nat Commun. 2026 Jan 22;17(1):1751
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory