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Klhl20 Gene Detail
Summary
  • Symbol
    Klhl20
  • Name
    kelch-like 20
  • Synonyms
    D930050H05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444855
    NCBI Gene: 226541
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:160915945-160959078 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1002 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444855
 protein coding gene Chr1:160915945-160959081 (-)
129S1/SvImJ ENSMUSG00200005741
 protein coding gene Chr1:158410382-158455011 (-)
A/J ENSMUSG00195021841
 protein coding gene Chr1:157735775-157780331 (-)
AKR/J ENSMUSG00220012726
 protein coding gene Chr1:157526593-157569730 (-)
BALB/cJ ENSMUSG00180035158
 protein coding gene Chr1:157966000-158016241 (-)
C3H/HeJ ENSMUSG00175036496
 protein coding gene Chr1:158045599-158090234 (-)
C57BL/6NJ ENSMUSG00215032876
 protein coding gene Chr1:157934857-157977991 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014761
 protein coding gene Chr1:151692991-151737983 (-)
CAST/EiJ ENSTCUG00005019572
 protein coding gene Chr1:156568749-156613462 (-)
CBA/J ENSMUSG00210020959
 protein coding gene Chr1:157943359-157987985 (-)
DBA/2J ENSMUSG00185041216
 protein coding gene Chr1:162184123-162234364 (-)
FVB/NJ ENSMUSG00205009579
 protein coding gene Chr1:157021647-157064776 (-)
JF1/MsJ ENSUMUG00000020074
 protein coding gene Chr1:161344848-161395098 (-)
LP/J ENSMUSG00230011605
 protein coding gene Chr1:161811770-161856347 (-)
NOD/ShiLtJ ENSMUSG00190033097
 protein coding gene Chr1:157773437-157816569 (-)
NZO/HlLtJ ENSMUSG00225004342
 protein coding gene Chr1:165422760-165465909 (-)
PWK/PhJ ENSLUMG00010036026
 protein coding gene Chr1:156731778-156775135 (-)
SPRET/EiJ ENSMSPG00010041508
 protein coding gene Chr1:160143046-160185669 (-)
WSB/EiJ ENSIUOG00005015182
 protein coding gene Chr1:157332101-157375251 (-)



Homology
more
  • Human Ortholog
    KLHL20, kelch like family member 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHL20, kelch like family member 20
  • Synonyms
    KHLHX, KLEIP, KLHLX, NEDSZFB
  • Links
    NCBI Gene ID: 27252
    UniProt: Q9Y2M5

  • Chr Location
    1q25.1; chr1:173714919-173786820 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption may exhibit male sterility. Mice homozygous for a gene trap allele exhibit corneal vascularization and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    631
  • Tissues
    8
  • cDNA Data
    14
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226541 NCBI Gene Model | MGI Sequence Detail 43134 C57BL/6J ±  kb
    transcript NM_001039482 RefSeq | MGI Sequence Detail 4037 C57BL/6  
    polypeptide Q8VCK5 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138280
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:232813 Liu CC, et al., Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. Mol Cell. 2016 Jan 7;61(1):84-97
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory