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Slc41a1 Gene Detail
Summary
  • Symbol
    Slc41a1
  • Name
    solute carrier family 41, member 1
  • Synonyms
    B230315F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444823
    NCBI Gene: 98396
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131755236-131776601 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 57.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    654 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444823
 protein coding gene Chr1:131755231-131776603 (+)
129S1/SvImJ ENSMUSG00200006781
 protein coding gene Chr1:129317212-129338786 (+)
A/J ENSMUSG00195038998
 protein coding gene Chr1:128417799-128439381 (+)
AKR/J ENSMUSG00220044051
 protein coding gene Chr1:128248701-128269928 (+)
BALB/cJ ENSMUSG00180036677
 protein coding gene Chr1:128964167-128985755 (+)
C3H/HeJ ENSMUSG00175037287
 protein coding gene Chr1:128662486-128684061 (+)
C57BL/6NJ ENSMUSG00215044539
 protein coding gene Chr1:128678154-128699730 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005031050
 protein coding gene Chr1:127583331-127605100 (+)
CBA/J ENSMUSG00210026421
 protein coding gene Chr1:128558987-128580565 (+)
DBA/2J ENSMUSG00185028798
 protein coding gene Chr1:132916058-132937633 (+)
FVB/NJ ENSMUSG00205033015
 protein coding gene Chr1:127895359-127916934 (+)
JF1/MsJ ENSUMUG00000040656
 protein coding gene Chr1:132077885-132099494 (+)
LP/J ENSMUSG00230035644
 protein coding gene Chr1:132503259-132524835 (+)
NOD/ShiLtJ ENSMUSG00190026301
 protein coding gene Chr1:128572358-128593934 (+)
NZO/HlLtJ ENSMUSG00225017285
 protein coding gene Chr1:136224489-136246021 (+)
PWK/PhJ ENSLUMG00010027606
 protein coding gene Chr1:127683369-127704937 (+)
SPRET/EiJ ENSMSPG00010043772
 protein coding gene Chr1:130500844-130519625 (+)
WSB/EiJ ENSIUOG00005043632
 protein coding gene Chr1:128305456-128326984 (+)



Homology
more
  • Human Ortholog
    SLC41A1, solute carrier family 41 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC41A1, solute carrier family 41 member 1
  • Synonyms
    MgtE, NPHPL2
  • Links
    NCBI Gene ID: 254428
    UniProt: Q8IVJ1

  • Chr Location
    1q32.1; chr1:205789091-205813755 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC41A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit partial rescue of the negative effects of magnesium starvation on Krebs cycle enzyme activity in cardiac mitochondria and increased electron transport chain complex I, III, IV, and V activities but decreased complex II activity irrespective of the type of magnesium diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    132
  • cDNA Data
    69
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 98396 NCBI Gene Model | MGI Sequence Detail 21366 C57BL/6J ±  kb
transcript NM_173865 RefSeq | MGI Sequence Detail 4675 C57BL/6  
polypeptide Q8BJA2 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015139 solute carrier family 41 member 1
    (term hierarchy)
  • InterPro Domains
    IPR045349 SLC41A divalent cation transporter
    IPR036739 SLC41A/MgtE divalent cation transporters, integral membrane domain superfamily
    IPR006667 SLC41A/MgtE, integral membrane domain
  • GlyGen
    Q8BJA2 1 site
Molecular
Reagents
less
  • All nucleic 71
    cDNA 69
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138291
References
more
  • Summaries
    All 47
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory