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Cracd Gene Detail
Summary
  • Symbol
    Cracd
  • Name
    capping protein inhibiting regulator of actin
  • Synonyms
    2810489J07Rik, 4930529A19Rik, 4931405B09Rik, C530008M17Rik, mKIAA1211
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444817
    NCBI Gene: 320827
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:76804359-77021392 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.34 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6798 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444817
 protein coding gene Chr5:76803225-77021393 (+)
129S1/SvImJ ENSMUSG00200000601
 protein coding gene Chr5:72494552-72496395 (+)
129S1/SvImJ ENSMUSG00200000606
 protein coding gene Chr5:72608361-72711701 (+)
A/J ENSMUSG00195010134
 protein coding gene Chr5:71809832-71811680 (+)
A/J ENSMUSG00195010138
 protein coding gene Chr5:71923563-72027384 (+)
AKR/J ENSMUSG00220014737
 protein coding gene Chr5:71921568-71923416 (+)
AKR/J ENSMUSG00220014742
 protein coding gene Chr5:72035300-72139142 (+)
BALB/cJ ENSMUSG00180019999
 protein coding gene Chr5:71680140-71783485 (+)
BALB/cJ ENSMUSG00180019981
 protein coding gene Chr5:71566309-71568152 (+)
C3H/HeJ ENSMUSG00175004115
 protein coding gene Chr5:73724598-73828425 (+)
C57BL/6NJ ENSMUSG00215000428
 protein coding gene Chr5:72494705-72598070 (+)
C57BL/6NJ ENSMUSG00215000427
 protein coding gene Chr5:72380876-72382719 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027319
 protein coding gene Chr5:69553289-69775349 (+)
CAST/EiJ ENSTCUGG00005054192
 protein coding gene Chr5:71553460-71575469 (+)
CBA/J ENSMUSG00210000417
 protein coding gene Chr5:72662547-72766375 (+)
DBA/2J ENSMUSG00185015627
 protein coding gene Chr5:74492499-74596322 (+)
FVB/NJ ENSMUSG00205019774
 protein coding gene Chr5:71450799-71554629 (+)
FVB/NJ ENSMUSG00205019756
 protein coding gene Chr5:71337065-71338913 (+)
JF1/MsJ ENSUMUGG00000058513
 protein coding gene Chr5:79061571-79083387 (+)
LP/J ENSMUSG00230019246
 protein coding gene Chr5:79068534-79070377 (+)
LP/J ENSMUSG00230019417
 protein coding gene Chr5:79182337-79285663 (+)
NOD/ShiLtJ ENSMUSGG00190054905
 protein coding gene Chr5:71692621-71714780 (+)
NOD/ShiLtJ ENSMUSG00190007632
 protein coding gene Chr5:71684521-71686493 (+)
NZO/HlLtJ ENSMUSG00225033745
 protein coding gene Chr5:84115522-84117365 (+)
NZO/HlLtJ ENSMUSG00225033756
 protein coding gene Chr5:84229329-84332655 (+)
PWK/PhJ ENSLUMGG00010054124
 protein coding gene Chr5:71636740-71662216 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005017779
 protein coding gene Chr5:74459648-74563484 (+)



Homology
more
  • Human Ortholog
    CRACD, capping protein inhibiting regulator of actin dynamics
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRACD, capping protein inhibiting regulator of actin dynamics
  • Synonyms
    CRAD, KIAA1211
  • Links
    NCBI Gene ID: 57482
    UniProt: Q6ZU35

  • Chr Location
    4q12; chr4:56049098-56330609 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    698
  • Tissues
    83
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036377 Ensembl Gene Model | MGI Sequence Detail 217034 C57BL/6J ±  kb
    transcript ENSMUST00000238963 Ensembl | MGI Sequence Detail 7096 Not Applicable  
    polypeptide ENSMUSP00000159046 Ensembl | MGI Sequence Detail 1376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 3

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1918189, MGI:1920065, MGI:1922397, MGI:6390555
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:378348 Seo Y, et al., Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer. Nat Commun. 2025 Dec 6;17(1):386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory