Atad2b MGI Mouse Gene Detail - MGI:2444798 - ATPase family, AAA domain containing 2B

Symbol

Atad2b
Name

ATPase family, AAA domain containing 2B
Synonyms

1110014E10Rik, D530031C13Rik

Feature Type

protein coding gene
IDs

MGI:2444798
NCBI Gene: 320817
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:4967353-5097394 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 2.15 cM
Mapping Data

2 experiments

SNPs within 2kb

532 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444798	protein coding gene	Chr12:4964404-5097396 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019579	protein coding gene	Chr12:1841029-1978890 (+)
A/J	MGP_AJ_G0019546	protein coding gene	Chr12:1798046-1932627 (+)
AKR/J	MGP_AKRJ_G0019516	protein coding gene	Chr12:1996072-2142751 (+)
BALB/cJ	MGP_BALBcJ_G0019521	protein coding gene	Chr12:1836694-1983293 (+)
C3H/HeJ	MGP_C3HHeJ_G0019327	protein coding gene	Chr12:1774742-1911639 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019970	protein coding gene	Chr12:1885508-2021262 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017595	protein coding gene	Chr12:1782413-1911460 (+)
CAST/EiJ	MGP_CASTEiJ_G0018882	protein coding gene	Chr12:1858925-1992368 (+)
CBA/J	MGP_CBAJ_G0019298	protein coding gene	Chr12:2197493-2356257 (+)
DBA/2J	MGP_DBA2J_G0019411	protein coding gene	Chr12:1735881-1867354 (+)
FVB/NJ	MGP_FVBNJ_G0019402	protein coding gene	Chr12:1752656-1878743 (+)
LP/J	MGP_LPJ_G0019482	protein coding gene	Chr12:1841297-1977197 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019435	protein coding gene	Chr12:1937778-2082122 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020009	protein coding gene	Chr12:1816328-1954256 (+)
PWK/PhJ	MGP_PWKPhJ_G0018648	protein coding gene	Chr12:1794877-1927991 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018439	protein coding gene	Chr12:1843088-1983032 (+)
WSB/EiJ	MGP_WSBEiJ_G0018933	protein coding gene	Chr12:1812697-1949600 (+)

Human Ortholog

ATAD2B, ATPase family AAA domain containing 2B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATAD2B, ATPase family AAA domain containing 2B
Links

HGNC:29230

NCBI Gene ID: 54454

neXtProt AC: NX_Q9ULI0

UniProt: Q9ULI0
Chr Location

2p24.1-p23.3; chr2:23677969-23927123 (-) GRCh38

MGI Vertebrate Homology

Atad2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATAD2B
Gene Tree

Atad2b

less

Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

54
Endonuclease-mediated

2
Gene trapped

48
Targeted

3
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

88 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit reduced body size and fertility in female mice.

less

All GO Annotations

10
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

75
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atad2b

less

All Sequences

61
RefSeq

13
UniProt

4
CCDS

CCDS49020.1

Ensembl

ENSMUSG00000052812 (Evidence)
NCBI Gene

320817

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052812	Ensembl Gene Model \| MGI Sequence Detail	130042	C57BL/6J	± kb
transcript	ENSMUST00000045664	Ensembl \| MGI Sequence Detail	8035	Not Applicable
polypeptide	ENSMUSP00000047445	Ensembl \| MGI Sequence Detail	1460	Not Applicable

less

UniProt

4 Sequences
InterPro Domains

IPR041569 AAA ATPase, AAA+ lid domain

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR045199 ATPase family AAA domain-containing protein ATAD2-like

IPR001487 Bromodomain

IPR018359 Bromodomain, conserved site

IPR036427 Bromodomain-like superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

less

All nucleic 77

Genomic 2

cDNA 75

Microarray probesets 4

less

MGI:1915840, MGI:2145096, MGI:3040673

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 13
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:306456 Farini D, et al., A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum. Cell Rep. 2020 Jun 2;31(9):107703

TSS for Atad2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112591	Chr12:4967300-4967307 (+)	-49 bp
Tssr112592	Chr12:4967332-4967343 (+)	-15 bp
Tssr112593	Chr12:4967346-4967370 (+)	5 bp
Tssr112594	Chr12:4967376-4967438 (+)	54 bp
Tssr112595	Chr12:4994912-4994933 (+)	27,570 bp
Tssr112596	Chr12:5006669-5006673 (+)	39,318 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23