Lmln MGI Mouse Gene Detail - MGI:2444736 - leishmanolysin-like (metallopeptidase M8 family)

Symbol

Lmln
Name

leishmanolysin-like (metallopeptidase M8 family)
Synonyms

5330415H22Rik

Feature Type

protein coding gene
IDs

MGI:2444736
NCBI Gene: 239833
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:32882891-32948065 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 23.60 cM
Mapping Data

2 experiments

SNPs within 2kb

2250 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444736	protein coding gene	Chr16:32881974-32948065 (+)
129S1/SvImJ	ENSMUSG00200035273	protein coding gene	Chr16:29904175-29969357 (+)
A/J	ENSMUSG00195028240	protein coding gene	Chr16:29442617-29507707 (+)
AKR/J	ENSMUSG00220028578	protein coding gene	Chr16:29728567-29793653 (+)
BALB/cJ	ENSMUSG00180029311	protein coding gene	Chr16:29658478-29723569 (+)
C3H/HeJ	ENSMUSG00175034047	protein coding gene	Chr16:29800388-29865466 (+)
C57BL/6NJ	ENSMUSG00215017987	protein coding gene	Chr16:29689070-29754254 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020686	protein coding gene	Chr16:30076828-30145110 (+)
CAST/EiJ	ENSTCUG00005031375	protein coding gene	Chr16:30072197-30136547 (+)
CBA/J	ENSMUSG00210034869	protein coding gene	Chr16:29842378-29907450 (+)
DBA/2J	ENSMUSG00185018410	protein coding gene	Chr16:29757860-29822931 (+)
FVB/NJ	ENSMUSG00205016901	protein coding gene	Chr16:29774040-29839131 (+)
JF1/MsJ	ENSUMUG00000032165	protein coding gene	Chr16:29974332-30040127 (+)
LP/J	ENSMUSG00230031767	protein coding gene	Chr16:32326563-32391635 (+)
NOD/ShiLtJ	ENSMUSG00190027669	protein coding gene	Chr16:29950669-30015823 (+)
NZO/HlLtJ	ENSMUSG00225039063	protein coding gene	Chr16:35562214-35628604 (+)
PWK/PhJ	ENSLUMG00010033224	protein coding gene	Chr16:29822141-29887327 (+)
SPRET/EiJ	ENSMSPG00010016984	protein coding gene	Chr16:29786228-29855567 (+)
WSB/EiJ	ENSIUOG00005033985	protein coding gene	Chr16:29938815-30003876 (+)

Human Ortholog

LMLN, leishmanolysin like peptidase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LMLN, leishmanolysin like peptidase
Synonyms

GP63, INV, IX14, LMNL1, MSP
Links

HGNC:15991

NCBI Gene ID: 89782

UniProt: Q96KR4
Chr Location

3q29; chr3:197960200-198043720 (+) GRCh38

MGI Vertebrate Homology

Lmln stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LMLN
Gene Tree

Lmln

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

6
Gene trapped

3
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lmln

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All Sequences

42
RefSeq

8
UniProt

1
CCDS

CCDS28127.1

Ensembl

ENSMUSG00000022802 (Evidence)
NCBI Gene

239833

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022802	Ensembl Gene Model \| MGI Sequence Detail	65175	C57BL/6J	± kb
transcript	ENSMUST00000023497	Ensembl \| MGI Sequence Detail	6147	Not Applicable
polypeptide	ENSMUSP00000023497	Ensembl \| MGI Sequence Detail	681	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009858 leishmanolysin-like peptidase

(term hierarchy)
EC

3.4.24.-
InterPro Domains

IPR001577 Peptidase M8, leishmanolysin
GlyGen

Q8BMN4 1 site, 1 N-linked glycan (1 site)

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All nucleic 8

Genomic 2

cDNA 6

Microarray probesets 4

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MGI:2146442

Summaries

All 34

Gene Ontology 6

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Lmln:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138079	Chr16:32882882-32882919 (+)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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