Lingo4 MGI Mouse Gene Detail - MGI:2444651 - leucine rich repeat and Ig domain containing 4

Symbol

Lingo4
Name

leucine rich repeat and Ig domain containing 4
Synonyms

A530050P17Rik, LERN4, Lrrn6d

Feature Type

protein coding gene
IDs

MGI:2444651
NCBI Gene: 320747
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr3:94306526-94311820 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.59 cM
Mapping Data

1 experiment

SNPs within 2kb

165 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444651	protein coding gene	Chr3:94305824-94311820 (+)
129S1/SvImJ	ENSMUSG00200037252	protein coding gene	Chr3:90969342-90975345 (+)
A/J	ENSMUSG00195044483	protein coding gene	Chr3:91296637-91302640 (+)
AKR/J	ENSMUSG00220048550	protein coding gene	Chr3:89683718-89689724 (+)
BALB/cJ	ENSMUSG00180036716	protein coding gene	Chr3:91278399-91284375 (+)
C3H/HeJ	ENSMUSG00175023331	protein coding gene	Chr3:90940368-90946370 (+)
C57BL/6NJ	ENSMUSG00215020041	protein coding gene	Chr3:91650112-91656097 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025309	protein coding gene	Chr3:88572273-88578240 (+)
CAST/EiJ	ENSTCUG00005045079	protein coding gene	Chr3:91486780-91492770 (+)
CBA/J	ENSMUSG00210050130	protein coding gene	Chr3:91477861-91483863 (+)
DBA/2J	ENSMUSG00185036152	protein coding gene	Chr3:91793872-91799873 (+)
FVB/NJ	ENSMUSG00205049073	protein coding gene	Chr3:90648553-90654558 (+)
JF1/MsJ	ENSUMUG00000034412	protein coding gene	Chr3:90784836-90790807 (+)
LP/J	ENSMUSG00230039155	protein coding gene	Chr3:93832885-93838888 (+)
NOD/ShiLtJ	ENSMUSG00190029773	protein coding gene	Chr3:91952249-91958235 (+)
NZO/HlLtJ	ENSMUSG00225010271	protein coding gene	Chr3:96240079-96246055 (+)
PWK/PhJ	ENSLUMG00010043213	protein coding gene	Chr3:90771108-90777084 (+)
SPRET/EiJ	ENSMSPG00010043498	protein coding gene	Chr3:91084371-91090328 (+)
WSB/EiJ	ENSIUOG00005024380	protein coding gene	Chr3:91409813-91415781 (+)

Human Ortholog

LINGO4, leucine rich repeat and Ig domain containing 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LINGO4, leucine rich repeat and Ig domain containing 4
Synonyms

DAAT9248, LRRN6D, PRO34002
Links

HGNC:31814

NCBI Gene ID: 339398

UniProt: Q6UY18
Chr Location

1q21.3; chr1:151800264-151805419 (-) GRCh38

MGI Vertebrate Homology

Lingo4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LINGO4
Gene Tree

Lingo4

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References

1 with disease annotations

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Lingo4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
Tissues

29
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lingo4

ZFIN lingo4b

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All Sequences

33
RefSeq

4
UniProt

2
CCDS

CCDS17592.1

Ensembl

ENSMUSG00000044505 (Evidence)
NCBI Gene

320747

			Length	Strain/Species	Flank
genomic	320747	NCBI Gene Model \| MGI Sequence Detail	5295	C57BL/6J	± kb
transcript	NM_001368653	RefSeq \| MGI Sequence Detail	4389	C57BL/6
polypeptide	Q149C3	UniProt \| EBI \| MGI Sequence Detail	593	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031008 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4

(term hierarchy)
InterPro Domains

IPR000483 Cysteine-rich flanking region, C-terminal

IPR003599 Immunoglobulin domain subtype

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q149C3 7 sites, 1 N-linked glycan (2 sites)

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 1

Summaries

All 31

Developmental Gene Expression 2

Diseases 1

Gene Ontology 2

Phenotypes 9
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Lingo4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30446	Chr3:94305842-94305845 (+)	-682 bp
Tssr30447	Chr3:94306579-94306640 (+)	84 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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