Kif20b MGI Mouse Gene Detail - MGI:2444576

Symbol

Kif20b
Name

kinesin family member 20B
Synonyms

33cex, C330014J10Rik, Kif20b, magoo, Mphosph1, N-6 kinesin

Feature Type

protein coding gene
IDs

MGI:2444576
NCBI Gene: 240641
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:34899761-34953145 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 29.79 cM
Mapping Data

5 experiments

SNPs within 2kb

357 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444576	protein coding gene	Chr19:34899735-34953150 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025067	protein coding gene	Chr19:33702331-33761723 (+)
A/J	MGP_AJ_G0025043	protein coding gene	Chr19:32070370-32128892 (+)
AKR/J	MGP_AKRJ_G0025011	protein coding gene	Chr19:33176587-33232566 (+)
BALB/cJ	MGP_BALBcJ_G0025041	protein coding gene	Chr19:32188341-32241656 (+)
C3H/HeJ	MGP_C3HHeJ_G0024800	protein coding gene	Chr19:33255712-33312655 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025482	protein coding gene	Chr19:34704110-34762321 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022900	protein coding gene	Chr19:31482165-31537472 (+)
CAST/EiJ	MGP_CASTEiJ_G0024267	protein coding gene	Chr19:33009508-33069691 (+)
CBA/J	MGP_CBAJ_G0024777	protein coding gene	Chr19:36325375-36383124 (+)
DBA/2J	MGP_DBA2J_G0024909	protein coding gene	Chr19:31965946-32019775 (+)
FVB/NJ	MGP_FVBNJ_G0024870	protein coding gene	Chr19:31793364-31846482 (+)
LP/J	MGP_LPJ_G0024995	protein coding gene	Chr19:33818405-33874976 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024901	protein coding gene	Chr19:36083492-36161007 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025540	protein coding gene	Chr19:33251561-33307461 (+)
PWK/PhJ	MGP_PWKPhJ_G0024019	protein coding gene	Chr19:31782732-31836898 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023819	protein coding gene	Chr19:32121192-32178235 (+)
WSB/EiJ	MGP_WSBEiJ_G0024334	protein coding gene	Chr19:33327805-33384950 (+)

Human Ortholog

KIF20B, kinesin family member 20B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF20B, kinesin family member 20B
Synonyms

CT90, KRMP1, MPHOSPH1, MPP1, MPP-1
Links

HGNC:7212

NCBI Gene ID: 9585

neXtProt AC: NX_Q96Q89

UniProt: Q96Q89
Chr Location

10q23.31; chr10:89701590-89774939 (+) GRCh38

MGI Vertebrate Homology

Kif20b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KIF20B
Gene Tree

Kif20b

Diseases

1 with Kif20b mouse models

Human Disease

Mouse Models

microcephaly

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

37 phenotypes from 3 alleles in 5 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (ENU)

3
Endonuclease-mediated

1
Gene trapped

16
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

69 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for ENU induced mutations display craniofacial and nervous system abnormalities including exencephaly, microcephaly, decreased forebrain size and impaired neuronal progenitor proliferation.

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All GO Annotations

65
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

5
cDNA Data

91
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif20b

ZFIN kif20ba, kif20bb

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All Sequences

77
RefSeq

19
UniProt

7
CCDS

CCDS37967.1, CCDS89382.1

Ensembl

ENSMUSG00000024795 (Evidence)
NCBI Gene

240641

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024795	Ensembl Gene Model \| MGI Sequence Detail	53385	C57BL/6J	± kb
transcript	ENSMUST00000087341	Ensembl \| MGI Sequence Detail	5564	Not Applicable
polypeptide	ENSMUSP00000084599	Ensembl \| MGI Sequence Detail	1774	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000010535 kinesin-like protein KIF20B

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR047149 Kinesin-like protein KIF11-like

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 91

cDNA 91

Microarray probesets 2

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MGI:2447029, MGI:3578175, MGI:4889064

Summaries

All 50

Developmental Gene Expression 3

Diseases 1

Gene Ontology 11

Phenotypes 17
Earliest

J:70760 Miki H, et al., All kinesin superfamily protein, KIF, genes in mouse and human. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7004-11
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Kif20b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156167	Chr19:34899751-34899804 (+)	17 bp
Tssr156168	Chr19:34899809-34899818 (+)	53 bp
Tssr156169	Chr19:34939233-34939268 (+)	39,490 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23