Dnah14 MGI Mouse Gene Detail - MGI:2444525 - dynein, axonemal, heavy chain 14

Symbol

Dnah14
Name

dynein, axonemal, heavy chain 14
Synonyms

A230079K17Rik, Dnahc14, Gm980, LOC381311

Feature Type

protein coding gene
IDs

MGI:2444525
NCBI Gene: 240960
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:181404158-181642306 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 84.83 cM
Mapping Data

2 experiments

SNPs within 2kb

5459 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444525	protein coding gene	Chr1:181404124-181643339 (+)
129S1/SvImJ	ENSMUSG00200022273	protein coding gene	Chr1:179158285-179402839 (+)
A/J	ENSMUSG00195039825	protein coding gene	Chr1:178760339-179000376 (+)
AKR/J	ENSMUSG00220019715	protein coding gene	Chr1:178009415-178254979 (+)
BALB/cJ	ENSMUSG00180035751	protein coding gene	Chr1:178809574-179054143 (+)
C3H/HeJ	ENSMUSG00175033829	protein coding gene	Chr1:178985307-179229866 (+)
C57BL/6NJ	ENSMUSG00215014384	protein coding gene	Chr1:178211030-178455583 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014994	protein coding gene	Chr1:171622080-171650741 (+)
CAST/EiJ	ENSTCUG00005040966	protein coding gene	Chr1:176736920-176981829 (+)
CBA/J	ENSMUSG00210018305	protein coding gene	Chr1:178649322-178894880 (+)
DBA/2J	ENSMUSG00185033533	protein coding gene	Chr1:183268740-183514296 (+)
FVB/NJ	ENSMUSG00205027398	protein coding gene	Chr1:177699864-177945427 (+)
JF1/MsJ	ENSUMUG00000003702	protein coding gene	Chr1:182249223-182493547 (+)
LP/J	ENSMUSG00230028643	protein coding gene	Chr1:182817580-183062123 (+)
NOD/ShiLtJ	ENSMUSG00190031534	protein coding gene	Chr1:178671132-178916935 (+)
NZO/HlLtJ	ENSMUSG00225009575	protein coding gene	Chr1:186576455-186818100 (+)
PWK/PhJ	ENSLUMG00010015856	protein coding gene	Chr1:177518799-177760907 (+)
SPRET/EiJ	ENSMSPG00010032299	protein coding gene	Chr1:180987092-181233370 (+)
WSB/EiJ	ENSIUOG00005010615	protein coding gene	Chr1:177871176-178110672 (+)

Human Ortholog

DNAH14, dynein axonemal heavy chain 14

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAH14, dynein axonemal heavy chain 14
Synonyms

C1orf67, Dnahc14, HL-18, HL18
Links

HGNC:2945

NCBI Gene ID: 127602

UniProt: Q0VDD8
Chr Location

1q42.12; chr1:224896262-225399292 (+) GRCh38

MGI Vertebrate Homology

Dnah14 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DNAH14
Gene Tree

Dnah14

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

2 involving Dnah14
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

131 strains or lines available

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All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

7

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnah14

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All Sequences

47
RefSeq

2
UniProt

6

Ensembl

ENSMUSG00000047369 (Evidence)
NCBI Gene

240960

			Length	Strain/Species	Flank
genomic	240960	NCBI Gene Model \| MGI Sequence Detail	238149	C57BL/6J	± kb
transcript	NM_001377039	RefSeq \| MGI Sequence Detail	13992	C57BL/6
polypeptide	NP_001363968	RefSeq \| MGI Sequence Detail	4599	C57BL/6

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UniProt

6 Sequences
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR054354 Dynein 2 heavy chain 1, cytoplasmic, ATPase lid domain

IPR026983 Dynein heavy chain

IPR043157 Dynein heavy chain, AAA1 domain, small subdomain

IPR041466 Dynein heavy chain, AAA 5 extension domain

IPR041658 Dynein heavy chain, AAA lid domain

IPR042219 Dynein heavy chain, AAA lid domain superfamily

IPR024317 Dynein heavy chain, AAA module D4

IPR035706 Dynein heavy chain, ATP-binding dynein motor region

IPR024743 Dynein heavy chain, coiled coil stalk

IPR041228 Dynein heavy chain, C-terminal domain

IPR043160 Dynein heavy chain, C-terminal domain, barrel region

IPR004273 Dynein heavy chain, D6 P-loop domain

IPR042222 Dynein heavy chain, domain 2, N-terminal

IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region

IPR013602 Dynein heavy chain, linker

IPR042228 Dynein heavy chain, linker, subdomain 3

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

A0A571BGC3 2 sites

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All nucleic 7

cDNA 7

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MGI:2685826

Summaries

All 21

Gene Ontology 4

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dnah14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10526	Chr1:181404138-181404143 (+)	-17 bp
Tssr10527	Chr1:181404150-181404181 (+)	8 bp
Tssr10528	Chr1:181404183-181404197 (+)	32 bp
Tssr10529	Chr1:181404209-181404214 (+)	54 bp
Tssr10530	Chr1:181631663-181631678 (+)	227,513 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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