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Thumpd1 Gene Detail
Summary
  • Symbol
    Thumpd1
  • Name
    THUMP domain containing 1
  • Synonyms
    6330575P11Rik, MGC:7161
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444479
    NCBI Gene: 233802
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:119314316-119320021 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.13 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444479
 protein coding gene Chr7:119314316-119322842 (-)
129S1/SvImJ ENSMUSG00200021371
 protein coding gene Chr7:105834448-105840153 (-)
A/J ENSMUSG00195032601
 protein coding gene Chr7:110352684-110358051 (-)
AKR/J ENSMUSG00220021742
 protein coding gene Chr7:103795141-103800846 (-)
BALB/cJ ENSMUSG00180027147
 protein coding gene Chr7:107015908-107021275 (-)
C3H/HeJ ENSMUSG00175021457
 protein coding gene Chr7:107729458-107734825 (-)
C57BL/6NJ ENSMUSG00215012308
 protein coding gene Chr7:106989633-106995338 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030382
 protein coding gene Chr7:121887676-121893450 (-)
CAST/EiJ ENSTCUG00005038152
 protein coding gene Chr7:110301973-110307763 (-)
CBA/J ENSMUSG00210022752
 protein coding gene Chr7:107451960-107457327 (-)
DBA/2J ENSMUSG00185042742
 protein coding gene Chr7:111802966-111808333 (-)
FVB/NJ ENSMUSG00205016531
 protein coding gene Chr7:107451911-107457616 (-)
JF1/MsJ ENSUMUG00000042999
 protein coding gene Chr7:116873374-116879114 (-)
LP/J ENSMUSG00230031711
 protein coding gene Chr7:117921199-117926904 (-)
NOD/ShiLtJ ENSMUSG00190020603
 protein coding gene Chr7:107665804-107671509 (-)
NZO/HlLtJ ENSMUSG00225039597
 protein coding gene Chr7:116159501-116164868 (-)
PWK/PhJ ENSLUMG00010009588
 protein coding gene Chr7:105996835-106002202 (-)
SPRET/EiJ ENSMSPG00010008642
 protein coding gene Chr7:107207940-107213743 (-)
WSB/EiJ ENSIUOG00005010837
 protein coding gene Chr7:108334533-108340238 (-)



Homology
more
  • Human Ortholog
    THUMPD1, THUMP domain 1 NAT10 acetyltransferase adaptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THUMPD1, THUMP domain 1 NAT10 acetyltransferase adaptor
  • Synonyms
    NEDSOA, Tan1
  • Links
    NCBI Gene ID: 55623
    UniProt: Q9NXG2

  • Chr Location
    16p12.3; chr16:20702816-20742084 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired prenatal survival, decreased growth, male and female infertility, and ovarian and testicular atrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    138
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030942 Ensembl Gene Model | MGI Sequence Detail 5706 C57BL/6J ±  kb
    transcript ENSMUST00000033236 Ensembl | MGI Sequence Detail 2689 Not Applicable  
    polypeptide ENSMUSP00000033236 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 138
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:363949 Thalalla Gamage S, et al., Transfer RNA acetylation regulates in vivo mammalian stress signaling. Sci Adv. 2025 Mar 21;11(12):eads2923
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory