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Cfap46 Gene Detail
Summary
  • Symbol
    Cfap46
  • Name
    cilia and flagella associated protein 46
  • Synonyms
    9330101J02Rik, E030019B06Rik, Ttc40
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444387
    NCBI Gene: 212124
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:139180867-139263733 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 84.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2563 from dbSNP Build 142
  • Strain Annotations
    25
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444387
 protein coding gene Chr7:139180830-139264701 (-)
129S1/SvImJ ENSMUSGG00200054470
 protein coding gene Chr7:125796969-125804863 (-)
129S1/SvImJ ENSMUSG00200041907
 protein coding gene Chr7:125820001-125827224 (-)
A/J ENSMUSGG00195055406
 protein coding gene Chr7:130273739-130281634 (-)
A/J ENSMUSG00195032133
 protein coding gene Chr7:130296772-130303995 (-)
AKR/J ENSMUSG00220027802
 protein coding gene Chr7:123779413-123786027 (-)
BALB/cJ ENSMUSGG00180055538
 protein coding gene Chr7:126971549-126979444 (-)
BALB/cJ ENSMUSG00180037760
 protein coding gene Chr7:126994581-127001804 (-)
C3H/HeJ ENSMUSG00175032372
 protein coding gene Chr7:127722876-127730099 (-)
C3H/HeJ ENSMUSGG00175054719
 protein coding gene Chr7:127699850-127707744 (-)
C57BL/6NJ ENSMUSGG00215055763
 protein coding gene Chr7:126966927-126974696 (-)
C57BL/6NJ ENSMUSG00215045724
 protein coding gene Chr7:126989855-126997023 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030619
 protein coding gene Chr7:141680339-141764644 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210026248
 protein coding gene Chr7:127455456-127462678 (-)
DBA/2J ENSMUSG00185014472
 protein coding gene Chr7:131759213-131766436 (-)
DBA/2J ENSMUSGG00185057446
 protein coding gene Chr7:131736181-131744075 (-)
FVB/NJ ENSMUSGG00205054134
 protein coding gene Chr7:127423071-127430965 (-)
FVB/NJ ENSMUSG00205035493
 protein coding gene Chr7:127446090-127453314 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230042261
 protein coding gene Chr7:137923011-137930234 (-)
LP/J ENSMUSGG00230055349
 protein coding gene Chr7:137899988-137907882 (-)
NOD/ShiLtJ ENSMUSG00190028438
 protein coding gene Chr7:127588368-127595591 (-)
NOD/ShiLtJ ENSMUSGG00190054608
 protein coding gene Chr7:127565343-127573237 (-)
NZO/HlLtJ ENSMUSG00225050788
 protein coding gene Chr7:136132730-136139898 (-)
NZO/HlLtJ ENSMUSGG00225055691
 protein coding gene Chr7:136109806-136117588 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010040044
 protein coding gene Chr7:127269487-127353241 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CFAP46, cilia and flagella associated protein 46
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CFAP46, cilia and flagella associated protein 46
  • Synonyms
    bA288G11.4, bA288G11.5, bB137A17.2, bB137A17.3, C10orf123, C10orf124, C10orf92, C10orf93, TTC40
  • Links
    NCBI Gene ID: 54777
    UniProt: Q8IYW2

  • Chr Location
    10q26.3; chr10:132808392-132942823 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049571 Ensembl Gene Model | MGI Sequence Detail 82867 C57BL/6J ±  kb
transcript ENSMUST00000129990 Ensembl | MGI Sequence Detail 8180 Not Applicable  
polypeptide ENSMUSP00000120186 Ensembl | MGI Sequence Detail 2641 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    12 Sequences
  • PDB
    9IJJ
  • InterPro Domains
    IPR057466 CFAP46, N-terminal TPR repeat
    IPR039586 Cilia- and flagella-associated protein 46
  • GlyGen
    E9Q2C0 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 2
Other
Accession IDs
less
MGI:2685016
References
more
  • Summaries
    All 31
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory