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Rapgef5 Gene Detail
Summary
  • Symbol
    Rapgef5
  • Name
    Rap guanine nucleotide exchange factor (GEF) 5
  • Synonyms
    D030051B22Rik, mKIAA0277, mr-gef
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444365
    NCBI Gene: 217944
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:117480146-117723472 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 63.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1977 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444365
 protein coding gene Chr12:117480099-117723472 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020184
 protein coding gene Chr12:120433029-120693660 (+)
A/J MGP_AJ_G0020140
 protein coding gene Chr12:116000554-116249195 (+)
AKR/J MGP_AKRJ_G0020115
 protein coding gene Chr12:119517490-119762990 (+)
BALB/cJ MGP_BALBcJ_G0020123
 protein coding gene Chr12:116424168-116670170 (+)
C3H/HeJ MGP_C3HHeJ_G0019927
 protein coding gene Chr12:119805919-120058213 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020570
 protein coding gene Chr12:124212643-124468400 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018182
 protein coding gene Chr12:112391172-112637081 (+)
CAST/EiJ MGP_CASTEiJ_G0019467
 protein coding gene Chr12:113651912-113909316 (+)
CBA/J MGP_CBAJ_G0019894
 protein coding gene Chr12:129115061-129377417 (+)
DBA/2J MGP_DBA2J_G0020011
 protein coding gene Chr12:115392967-115641526 (+)
FVB/NJ MGP_FVBNJ_G0019996
 protein coding gene Chr12:114071331-114317852 (+)
LP/J MGP_LPJ_G0020085
 protein coding gene Chr12:120472211-120728838 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020032
 protein coding gene Chr12:132381771-132636305 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020599
 protein coding gene Chr12:118689945-118937297 (+)
PWK/PhJ MGP_PWKPhJ_G0019229
 protein coding gene Chr12:110144725-110394397 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019034
 protein coding gene Chr12:111644233-111898677 (+)
WSB/EiJ MGP_WSBEiJ_G0019525
 protein coding gene Chr12:119663030-119917285 (+)



Homology
more
  • Human Ortholog
    RAPGEF5, Rap guanine nucleotide exchange factor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAPGEF5, Rap guanine nucleotide exchange factor 5
  • Synonyms
    GFR, MRGEF, MR-GEF, REPAC
  • Links
    NCBI Gene ID: 9771
    neXtProt AC: NX_Q92565
    UniProt: Q92565

  • Chr Location
    7p15.3; chr7:22118236-22357154 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    177
  • cDNA Data
    96
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217944 NCBI Gene Model | MGI Sequence Detail 243327 C57BL/6J ±  kb
    transcript NM_175930 RefSeq | MGI Sequence Detail 6699 C57BL/6  
    polypeptide Q8C0Q9 UniProt | EBI | MGI Sequence Detail 814 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000013730 Rap guanine nucleotide exchange factor 5
      (term hierarchy)
    • InterPro Domains
      IPR000591 DEP domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR019804 Ras guanine-nucleotide exchange factor, conserved site
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
      IPR029071 Ubiquitin-like domain superfamily
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 96
      Primer pair 2
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2141775
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 8
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:283040 McKenzie MG, et al., Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons. Neuron. 2019 Sep 4;103(5):853-864.e4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory