About   Help   FAQ
Arhgap11a Gene Detail
Summary
  • Symbol
    Arhgap11a
  • Name
    Rho GTPase activating protein 11A
  • Synonyms
    6530401L14Rik, GAP (1-12), mKIAA0013
  • Feature Type
    protein coding gene
  • IDs
    MGI:2444300
    NCBI Gene: 228482
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:113661837-113679006 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 57.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2444300
 protein coding gene Chr2:113661837-113679006 (-)
129S1/SvImJ ENSMUSG00200006601
 protein coding gene Chr2:110549720-110566889 (-)
A/J ENSMUSG00195028176
 protein coding gene Chr2:110613559-110630635 (-)
AKR/J ENSMUSG00220004818
 protein coding gene Chr2:110509001-110525675 (-)
BALB/cJ ENSMUSG00180031819
 protein coding gene Chr2:110408791-110425867 (-)
C3H/HeJ ENSMUSG00175028754
 protein coding gene Chr2:110850088-110867164 (-)
C57BL/6NJ ENSMUSG00215024013
 protein coding gene Chr2:110563673-110580842 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024100
 protein coding gene Chr2:106740559-106757698 (-)
CAST/EiJ ENSTCUG00005005577
 protein coding gene Chr2:109792686-109809380 (-)
CBA/J ENSMUSG00210038138
 protein coding gene Chr2:110682647-110699782 (-)
DBA/2J ENSMUSG00185039228
 protein coding gene Chr2:110405106-110422182 (-)
FVB/NJ ENSMUSG00205013272
 protein coding gene Chr2:109663630-109680304 (-)
JF1/MsJ ENSUMUG00000002832
 protein coding gene Chr2:110242052-110259120 (-)
LP/J ENSMUSG00230004279
 protein coding gene Chr2:112211830-112228999 (-)
NOD/ShiLtJ ENSMUSG00190015537
 protein coding gene Chr2:110643593-110660267 (-)
NZO/HlLtJ ENSMUSG00225012758
 protein coding gene Chr2:120101229-120118364 (-)
PWK/PhJ ENSLUMG00010002880
 protein coding gene Chr2:110166480-110183457 (-)
SPRET/EiJ ENSMSPG00010031016
 protein coding gene Chr2:112421010-112437507 (-)
WSB/EiJ ENSIUOG00005030557
 protein coding gene Chr2:110336667-110353374 (-)



Homology
more
  • Human Ortholog
    ARHGAP11A, Rho GTPase activating protein 11A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP11A, Rho GTPase activating protein 11A
  • Synonyms
    GAP (1-12)
  • Links
    NCBI Gene ID: 9824
    UniProt: Q6P4F7

  • Chr Location
    15q13.3; chr15:32615144-32639952 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from multigenic genotypes
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1014
  • Tissues
    197
  • cDNA Data
    12
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 228482 NCBI Gene Model | MGI Sequence Detail 17170 C57BL/6J ±  kb
transcript NM_181416 RefSeq | MGI Sequence Detail 5017 C57BL/6  
polypeptide Q80Y19 UniProt | EBI | MGI Sequence Detail 987 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 13
    Primer pair 2
    Other 2
    Antibodies 2

    Microarray probesets 3
References
more
  • Summaries
    All 45
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:378639 Hass Y, et al., ARHGAP11A maintains cortical progenitor identity through RHOA-ROCK signaling during human brain development. Cell Rep. 2025 Dec 23;44(12):116599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory