Zzef1 MGI Mouse Gene Detail - MGI:2444286 - zinc finger, ZZ-type with EF hand domain 1

Symbol

Zzef1
Name

zinc finger, ZZ-type with EF hand domain 1
Synonyms

8430405D05Rik, C130099L13Rik, mKIAA0399

Feature Type

protein coding gene
IDs

MGI:2444286
NCBI Gene: 195018
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:72687052-72817946 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 44.56 cM
Mapping Data

2 experiments

SNPs within 2kb

2002 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444286	protein coding gene	Chr11:72686976-72817946 (+)
129S1/SvImJ	ENSMUSG00200046918	protein coding gene	Chr11:69727986-69860596 (+)
A/J	ENSMUSG00195052511	protein coding gene	Chr11:69657863-69790771 (+)
AKR/J	ENSMUSG00220039879	protein coding gene	Chr11:69904085-70036589 (+)
BALB/cJ	ENSMUSG00180052935	protein coding gene	Chr11:69825775-69958567 (+)
C3H/HeJ	ENSMUSG00175054346	protein coding gene	Chr11:69773045-69905821 (+)
C57BL/6NJ	ENSMUSG00215052992	protein coding gene	Chr11:69456693-69589487 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016680	protein coding gene	Chr11:67514422-67640223 (+)
CAST/EiJ	ENSTCUG00005053069	protein coding gene	Chr11:69319930-69452829 (+)
CBA/J	ENSMUSG00210051666	protein coding gene	Chr11:69627028-69759795 (+)
DBA/2J	ENSMUSG00185055895	protein coding gene	Chr11:69905984-70041542 (+)
FVB/NJ	ENSMUSG00205024983	protein coding gene	Chr11:69744321-69877110 (+)
JF1/MsJ	ENSUMUG00000045972	protein coding gene	Chr11:70299177-70434754 (+)
LP/J	ENSMUSG00230047087	protein coding gene	Chr11:70939012-71071610 (+)
NOD/ShiLtJ	ENSMUSG00190054104	protein coding gene	Chr11:69900095-70032882 (+)
NZO/HlLtJ	ENSMUSG00225036585	protein coding gene	Chr11:73123262-73255909 (+)
PWK/PhJ	ENSLUMG00010038620	protein coding gene	Chr11:69782041-69917826 (+)
SPRET/EiJ	ENSMSPG00010045956	protein coding gene	Chr11:70342856-70473488 (+)
WSB/EiJ	ENSIUOG00005040713	protein coding gene	Chr11:69855815-69988745 (+)

Human Ortholog

ZZEF1, zinc finger ZZ-type and EF-hand domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZZEF1, zinc finger ZZ-type and EF-hand domain containing 1
Synonyms

ZZZ4
Links

HGNC:29027

NCBI Gene ID: 23140

UniProt: O43149
Chr Location

17p13.2; chr17:4004445-4143628 (-) GRCh38

MGI Vertebrate Homology

Zzef1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZZEF1
Gene Tree

Zzef1

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Phenotype Summary

15 phenotypes from 1 allele in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

4
Targeted

4
Genomic Mutations

2 involving Zzef1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

129 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

54
cDNA Data

11
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zzef1

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All Sequences

62
RefSeq

12
UniProt

3
CCDS

CCDS36218.1

Ensembl

ENSMUSG00000055670 (Evidence)
NCBI Gene

195018

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055670	Ensembl Gene Model \| MGI Sequence Detail	130895	C57BL/6J	± kb
transcript	ENSMUST00000207107	Ensembl \| MGI Sequence Detail	11306	Not Applicable
polypeptide	ENSMUSP00000147028	Ensembl \| MGI Sequence Detail	2953	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000030694 zinc finger ZZ-type and EF-hand domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR004939 APC10/DOC domain

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR008979 Galactose-binding-like domain superfamily

IPR000433 Zinc finger, ZZ-type

IPR040099 Zinc finger ZZ-type and EF-hand domain-containing protein 1

IPR047052 Zinc finger ZZ-type and EF-hand domain-containing protein 1, APC10/DOC1-like domain

IPR043145 Zinc finger, ZZ-type superfamily

IPR041986 ZZEF1, zinc finger, ZZ-type
GlyGen

Q5SSH7 2 sites

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All nucleic 11

cDNA 11

Microarray probesets 5

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MGI:1918726, MGI:2144680, MGI:3039564

Summaries

All 53

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 23
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:377419 Nan J, et al., Single-cell perturbations decipher ribosomal stress-surveillance regulators in type 2 diabetes. Nat Metab. 2026 Jan 2;

TSS for Zzef1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102857	Chr11:72686990-72687072 (+)	-21 bp
Tssr102858	Chr11:72687083-72687094 (+)	37 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24