Zcchc2 MGI Mouse Gene Detail - MGI:2444114 - zinc finger, CCHC domain containing 2

Symbol

Zcchc2
Name

zinc finger, CCHC domain containing 2
Synonyms

9930114B20Rik

Feature Type

protein coding gene
IDs

MGI:2444114
NCBI Gene: 227449
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr1:105918136-105961804 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 49.76 cM
Mapping Data

2 experiments

SNPs within 2kb

314 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2444114	protein coding gene	Chr1:105916929-105961807 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016369	protein coding gene	Chr1:108131798-108176010 (+)
A/J	MGP_AJ_G0016353	protein coding gene	Chr1:104349336-104392992 (+)
AKR/J	MGP_AKRJ_G0016313	protein coding gene	Chr1:107214719-107258389 (+)
BALB/cJ	MGP_BALBcJ_G0016309	protein coding gene	Chr1:104446808-104490465 (+)
C3H/HeJ	MGP_C3HHeJ_G0016136	protein coding gene	Chr1:107654073-107698452 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016768	protein coding gene	Chr1:112279137-112324254 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014486	protein coding gene	Chr1:98690291-98735108 (+)
CAST/EiJ	MGP_CASTEiJ_G0015718	protein coding gene	Chr1:106569777-106615095 (+)
CBA/J	MGP_CBAJ_G0016109	protein coding gene	Chr1:116109402-116155656 (+)
DBA/2J	MGP_DBA2J_G0016214	protein coding gene	Chr1:103418891-103462563 (+)
FVB/NJ	MGP_FVBNJ_G0016215	protein coding gene	Chr1:102357900-102401550 (+)
LP/J	MGP_LPJ_G0016288	protein coding gene	Chr1:109388665-109432322 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016241	protein coding gene	Chr1:120554928-120598583 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016807	protein coding gene	Chr1:107295606-107339266 (+)
PWK/PhJ	MGP_PWKPhJ_G0015505	protein coding gene	Chr1:102453708-102497484 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015290	protein coding gene	Chr1:105961428-106005997 (+)
WSB/EiJ	MGP_WSBEiJ_G0015781	protein coding gene	Chr1:107132862-107176533 (+)

Human Ortholog

ZCCHC2, zinc finger CCHC-type containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZCCHC2, zinc finger CCHC-type containing 2
Synonyms

C18orf49
Links

HGNC:22916

NCBI Gene ID: 54877

neXtProt AC: NX_Q9C0B9

UniProt: Q9C0B9
Chr Location

18q21.33; chr18:62523025-62587709 (+) GRCh38

Alliance of Genome Resources

Zcchc2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZCCHC2
Gene Tree

Zcchc2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Zcchc2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

3
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zcchc2

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Zcchc2 interacts with 420 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

69
RefSeq

23
UniProt

4
CCDS

CCDS48335.1, CCDS48336.1

Ensembl

ENSMUSG00000038866 (Evidence)
NCBI Gene

227449

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038866	Ensembl Gene Model \| MGI Sequence Detail	43669	C57BL/6J	± kb
transcript	ENSMUST00000118196	Ensembl \| MGI Sequence Detail	5796	Not Applicable
polypeptide	ENSMUSP00000113974	Ensembl \| MGI Sequence Detail	1166	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000032377 zinc finger CCHC domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR036871 PX domain superfamily

IPR042793 Zinc finger CCHC domain-containing protein 2

IPR001878 Zinc finger, CCHC-type

IPR036875 Zinc finger, CCHC-type superfamily

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All nucleic 9

cDNA 9

Microarray probesets 5

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MGI:2138574

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Zcchc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8279	Chr1:105917515-105917528 (+)	-614 bp
Tssr8280	Chr1:105917918-105917939 (+)	-207 bp
Tssr8281	Chr1:105918114-105918228 (+)	35 bp
Tssr8282	Chr1:105918382-105918448 (+)	279 bp
Tssr172	Chr1:105918451-105918480 (+)	330 bp
Tssr8283	Chr1:105918482-105918502 (+)	356 bp
Tssr8284	Chr1:105918506-105918543 (+)	389 bp
Tssr173	Chr1:105918547-105918561 (+)	418 bp
Tssr8285	Chr1:105918703-105918729 (+)	580 bp
Tssr8286	Chr1:105919245-105919299 (+)	1,136 bp
Tssr8287	Chr1:105921691-105921713 (+)	3,566 bp
Tssr8288	Chr1:105930573-105930578 (+)	12,440 bp
Tssr8289	Chr1:105949867-105949876 (+)	31,736 bp
Tssr8290	Chr1:105954109-105954112 (+)	35,975 bp
Tssr8291	Chr1:105961377-105961421 (+)	43,263 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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