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Mmp25 Gene Detail
Summary
  • Symbol
    Mmp25
  • Name
    matrix metallopeptidase 25
  • Synonyms
    F730048C11Rik, Leukolysin, MT6-MMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443938
    NCBI Gene: 240047
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23847289-23864243 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 11.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443938
 protein coding gene Chr17:23847285-23864251 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023259
 protein coding gene Chr17:22532716-22554162 (-)
A/J MGP_AJ_G0023219
 protein coding gene Chr17:21891572-21908430 (-)
AKR/J MGP_AKRJ_G0023189
 protein coding gene Chr17:21970199-21985857 (-)
BALB/cJ MGP_BALBcJ_G0023224
 protein coding gene Chr17:22107550-22124652 (-)
C3H/HeJ MGP_C3HHeJ_G0022984
 protein coding gene Chr17:22328871-22346919 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023667
 protein coding gene Chr17:23519240-23535883 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021148
 protein coding gene Chr17:19464503-19480058 (-)
CAST/EiJ MGP_CASTEiJ_G0022490
 protein coding gene Chr17:22162146-22179923 (-)
CBA/J MGP_CBAJ_G0022960
 protein coding gene Chr17:24313919-24341051 (-)
DBA/2J MGP_DBA2J_G0023092
 protein coding gene Chr17:21520718-21538914 (-)
FVB/NJ MGP_FVBNJ_G0023059
 protein coding gene Chr17:21243952-21263766 (-)
LP/J MGP_LPJ_G0023166
 protein coding gene Chr17:22790769-22807045 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023078
 protein coding gene Chr17:24092290-24110511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023706
 protein coding gene Chr17:22256371-22273016 (-)
PWK/PhJ MGP_PWKPhJ_G0022238
 protein coding gene Chr17:20307224-20323808 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022058
 protein coding gene Chr17:20285913-20301445 (-)
WSB/EiJ MGP_WSBEiJ_G0022553
 protein coding gene Chr17:22314448-22332526 (-)



Homology
more
  • Human Ortholog
    MMP25, matrix metallopeptidase 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP25, matrix metallopeptidase 25
  • Synonyms
    MMP20, MMP20A, MMP-25, MMPL1, MT6MMP, MT6-MMP, MTMMP6, MT-MMP6, MT-MMP 6
  • Links
    NCBI Gene ID: 64386
    neXtProt AC: NX_Q9NPA2
    UniProt: Q9NPA2

  • Chr Location
    16p13.3; chr16:3045963-3060729 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    14
  • cDNA Data
    13
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 240047 NCBI Gene Model | MGI Sequence Detail 16955 C57BL/6J ±  kb
transcript NM_001033339 RefSeq | MGI Sequence Detail 3670 C57BL/6  
polypeptide Q3U435 UniProt | EBI | MGI Sequence Detail 615 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:294100 Kyprianou C, et al., Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020 Jun;582(7811):253-258
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/14/2023
MGI 6.22 		The Jackson Laboratory