Dmxl1 MGI Mouse Gene Detail - MGI:2443926

Symbol

Dmxl1
Name

Dmx-like 1
Synonyms

C630007L23Rik

Feature Type

protein coding gene
IDs

MGI:2443926
NCBI Gene: 240283
Alliance

genome feature page
Transcription Start Sites

10 TSS

Sequence Map

Chr18:49965737-50098540 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 27.12 cM
Mapping Data

2 experiments

SNPs within 2kb

2598 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443926	protein coding gene	Chr18:49965657-50098540 (+)
129S1/SvImJ	ENSMUSG00200028494	protein coding gene	Chr18:47005788-47138648 (+)
A/J	ENSMUSG00195025016	protein coding gene	Chr18:47155784-47288661 (+)
AKR/J	ENSMUSG00220021071	protein coding gene	Chr18:47101948-47234825 (+)
BALB/cJ	ENSMUSG00180007561	protein coding gene	Chr18:47675973-47809503 (+)
C3H/HeJ	ENSMUSG00175010716	protein coding gene	Chr18:47274591-47408127 (+)
C57BL/6NJ	ENSMUSG00215006235	protein coding gene	Chr18:46695977-46828782 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022264	protein coding gene	Chr18:46697963-46828898 (+)
CAST/EiJ	ENSTCUG00005013222	protein coding gene	Chr18:46576042-46708417 (+)
CBA/J	ENSMUSG00210022190	protein coding gene	Chr18:47233618-47367145 (+)
DBA/2J	ENSMUSG00185027296	protein coding gene	Chr18:47134595-47268124 (+)
FVB/NJ	ENSMUSG00205012055	protein coding gene	Chr18:46610722-46744266 (+)
JF1/MsJ	ENSUMUG00000023750	protein coding gene	Chr18:47123940-47256835 (+)
LP/J	ENSMUSG00230025159	protein coding gene	Chr18:49182404-49315261 (+)
NOD/ShiLtJ	ENSMUSG00190024192	protein coding gene	Chr18:46918449-47051979 (+)
NZO/HlLtJ	ENSMUSG00225027388	protein coding gene	Chr18:49085109-49217982 (+)
PWK/PhJ	ENSLUMG00010021412	protein coding gene	Chr18:47240041-47372089 (+)
SPRET/EiJ	ENSMSPG00010012674	protein coding gene	Chr18:47553176-47683058 (+)
WSB/EiJ	ENSIUOG00005009305	protein coding gene	Chr18:46828025-46961531 (+)

Human Ortholog

DMXL1, Dmx like 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DMXL1, Dmx like 1
Links

HGNC:2937

NCBI Gene ID: 1657

UniProt: Q9Y485
Chr Location

5q23.1; chr5:119037772-119249138 (+) GRCh38

MGI Vertebrate Homology

Dmxl1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DMXL1
Gene Tree

Dmxl1

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Phenotype Summary

3 phenotypes from 4 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

6
Gene trapped

13
Spontaneous

1
Genomic Mutations

1 involving Dmxl1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

159 strains or lines available

Mice homozygous for a small deletion die prior to E9.5.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

654
Tissues

10
cDNA Data

54
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dmxl1

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All Sequences

58
RefSeq

10
UniProt

5
CCDS

CCDS37816.2

Ensembl

ENSMUSG00000037416 (Evidence)
NCBI Gene

240283

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037416	Ensembl Gene Model \| MGI Sequence Detail	132804	C57BL/6J	± kb
transcript	ENSMUST00000041772	Ensembl \| MGI Sequence Detail	12247	Not Applicable
polypeptide	ENSMUSP00000045559	Ensembl \| MGI Sequence Detail	3025	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006552 DmX-like protein 1

(term hierarchy)
InterPro Domains

IPR052208 DmX-like/RAVE complex component

IPR022033 RAVE complex protein Rav1 C-terminal

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q6PNC0 2 sites, 1 N-linked glycan (1 site)

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All nucleic 58

cDNA 55

Primer pair 2

Other 1

Antibodies 2

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 12
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:385562 Winkley SR, et al., The ROGDI protein mutated in Kohlschutter-Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly. J Biol Chem. 2025 Mar 4;301(4):108381

TSS for Dmxl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150983	Chr18:49965659-49965672 (+)	-71 bp
Tssr150984	Chr18:49965689-49965753 (+)	-16 bp
Tssr150985	Chr18:49965757-49965766 (+)	25 bp
Tssr150986	Chr18:49968954-49968982 (+)	3,231 bp
Tssr150987	Chr18:49973809-49973814 (+)	8,075 bp
Tssr150988	Chr18:50013800-50013813 (+)	48,070 bp
Tssr150989	Chr18:50017992-50018001 (+)	52,260 bp
Tssr150990	Chr18:50043491-50043506 (+)	77,762 bp
Tssr150991	Chr18:50070555-50070562 (+)	104,822 bp
Tssr150992	Chr18:50078284-50078294 (+)	112,552 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24