Thsd7b MGI Mouse Gene Detail - MGI:2443925 - thrombospondin, type I, domain containing 7B

Symbol

Thsd7b
Name

thrombospondin, type I, domain containing 7B
Synonyms

1700074E13Rik, D130067I03Rik

Feature Type

protein coding gene
IDs

MGI:2443925
NCBI Gene: 210417
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:129201039-130147015 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.55 cM
Mapping Data

1 experiment

SNPs within 2kb

38061 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443925	protein coding gene	Chr1:129201010-130147015 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016432	protein coding gene	Chr1:132580174-133540512 (+)
A/J	MGP_AJ_G0016415	protein coding gene	Chr1:127622367-128561597 (+)
AKR/J	MGP_AKRJ_G0016380	protein coding gene	Chr1:131411988-132388278 (+)
BALB/cJ	MGP_BALBcJ_G0016375	protein coding gene	Chr1:127996094-128941339 (+)
C3H/HeJ	MGP_C3HHeJ_G0016201	protein coding gene	Chr1:131564318-132525317 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016836	protein coding gene	Chr1:137542691-138526720 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014550	protein coding gene	Chr1:120915614-121796062 (+)
CAST/EiJ	MGP_CASTEiJ_G0015782	protein coding gene	Chr1:130573006-131556401 (+)
CBA/J	MGP_CBAJ_G0016174	protein coding gene	Chr1:142207458-143278920 (+)
DBA/2J	MGP_DBA2J_G0016280	protein coding gene	Chr1:126658025-127572622 (+)
FVB/NJ	MGP_FVBNJ_G0016279	protein coding gene	Chr1:125350659-126272850 (+)
LP/J	MGP_LPJ_G0016351	protein coding gene	Chr1:133927630-134902986 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016304	protein coding gene	Chr1:148002367-149092547 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016872	protein coding gene	Chr1:131187430-132159833 (+)
PWK/PhJ	MGP_PWKPhJ_G0015568	protein coding gene	Chr1:125634190-126561951 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015356	protein coding gene	Chr1:130134058-131099664 (+)
WSB/EiJ	MGP_WSBEiJ_G0015844	protein coding gene	Chr1:131136731-132124568 (+)

Human Ortholog

THSD7B, thrombospondin type 1 domain containing 7B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THSD7B, thrombospondin type 1 domain containing 7B
Links

HGNC:29348

NCBI Gene ID: 80731

neXtProt AC: NX_Q9C0I4

UniProt: Q9C0I4
Chr Location

2q22.1; chr2:136765545-137677718 (+) GRCh38

MGI Vertebrate Homology

Thsd7b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: THSD7B
Gene Tree

Thsd7b

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Thsd7b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

96 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

707
Tissues

1
cDNA Data

22
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thsd7b

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All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS15255.1

Ensembl

ENSMUSG00000042581 (Evidence)
NCBI Gene

210417

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042581	Ensembl Gene Model \| MGI Sequence Detail	945977	C57BL/6J	± kb
transcript	ENSMUST00000073527	Ensembl \| MGI Sequence Detail	6213	Not Applicable
polypeptide	ENSMUSP00000073220	Ensembl \| MGI Sequence Detail	1607	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032684 thrombospondin type-1 domain-containing protein 7B

(term hierarchy)
InterPro Domains

IPR044004 Spondin-like TSP1 domain

IPR051418 Spondin/Thrombospondin type-1 domain-containing

IPR000884 Thrombospondin type-1 (TSP1) repeat

IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
GlyGen

Q6P4U0 16 sites, 7 N-linked glycans (5 sites)

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 3

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MGI:1925716

Summaries

All 34

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Thsd7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8548	Chr1:129201173-129201207 (+)	151 bp
Tssr8549	Chr1:129201208-129201219 (+)	175 bp
Tssr8550	Chr1:129201228-129201235 (+)	193 bp
Tssr8551	Chr1:129608733-129608744 (+)	407,700 bp
Tssr8552	Chr1:130091564-130091571 (+)	890,529 bp
Tssr8553	Chr1:130091593-130091604 (+)	890,560 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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