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Lipi Gene Detail
Summary
  • Symbol
    Lipi
  • Name
    lipase I
  • Synonyms
    D930038D03Rik, lpd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443868
    NCBI Gene: 320355
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:75337431-75382960 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 43.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1467 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443868
 protein coding gene Chr16:75337402-75382960 (-)
129S1/SvImJ ENSMUSG00200015586
 protein coding gene Chr16:72223990-72269538 (-)
A/J ENSMUSG00195022193
 protein coding gene Chr16:72006181-72051736 (-)
AKR/J ENSMUSG00220017430
 protein coding gene Chr16:72172369-72217916 (-)
BALB/cJ ENSMUSG00180001987
 protein coding gene Chr16:72073947-72119493 (-)
C3H/HeJ ENSMUSG00175008929
 protein coding gene Chr16:72347341-72392888 (-)
C57BL/6NJ ENSMUSG00215001647
 protein coding gene Chr16:72181839-72227385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020873
 protein coding gene Chr16:70819083-70860169 (-)
CAST/EiJ ENSTCUG00005007163
 protein coding gene Chr16:72102687-72149938 (-)
CBA/J ENSMUSG00210019507
 protein coding gene Chr16:72302249-72347795 (-)
DBA/2J ENSMUSG00185005013
 protein coding gene Chr16:72241038-72286591 (-)
FVB/NJ ENSMUSG00205013408
 protein coding gene Chr16:72030760-72076306 (-)
JF1/MsJ ENSUMUG00000011139
 protein coding gene Chr16:72458086-72504579 (-)
LP/J ENSMUSG00230018460
 protein coding gene Chr16:74797762-74843310 (-)
NOD/ShiLtJ ENSMUSG00190010851
 protein coding gene Chr16:72217808-72263352 (-)
NZO/HlLtJ ENSMUSG00225029332
 protein coding gene Chr16:78037536-78082538 (-)
PWK/PhJ ENSLUMG00010004753
 protein coding gene Chr16:72119701-72165289 (-)
SPRET/EiJ ENSMSPG00010014585
 protein coding gene Chr16:72932243-72976077 (-)
WSB/EiJ ENSIUOG00005017115
 protein coding gene Chr16:72241048-72286592 (-)



Homology
more
  • Human Ortholog
    LIPI, lipase I
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIPI, lipase I
  • Synonyms
    CT17, LPDL, mPA-PLA1 beta, PLA1C, PRED5
  • Links
    NCBI Gene ID: 149998
    UniProt: Q6XZB0

  • Chr Location
    21q11.2; chr21:14108812-14210955 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit postnatal lethality, tremors, abnormal gait, decreased body weight, retarded hair growth, and a defect in triglyceride metabolism resulting in hypertriglyceridemia and hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    615
  • Tissues
    2
  • cDNA Data
    4
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 320355 NCBI Gene Model | MGI Sequence Detail 45530 C57BL/6J ±  kb
    transcript NM_001252513 RefSeq | MGI Sequence Detail 2023 C57BL/6  
    polypeptide NP_001239442 RefSeq | MGI Sequence Detail 476 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:46789 Wen XY, et al., Characterization of lpd (lipid defect): a novel mutation on mouse chromosome 16 associated with a defect in triglyceride metabolism. Hum Mol Genet. 1998 Apr;7(4):743-50
    • Latest
      J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory