Mat2a MGI Mouse Gene Detail - MGI:2443731 - methionine adenosyltransferase 2A

Symbol

Mat2a
Name

methionine adenosyltransferase 2A
Synonyms

D630045P18Rik, MGC:6545

Feature Type

protein coding gene
IDs

MGI:2443731
NCBI Gene: 232087
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:72409782-72416541 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.27 cM
Mapping Data

1 experiment

SNPs within 2kb

21 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443731	protein coding gene	Chr6:72409779-72416541 (-)
129S1/SvImJ	ENSMUSG00200010387	protein coding gene	Chr6:69313848-69320607 (-)
A/J	ENSMUSG00195041498	protein coding gene	Chr6:69076061-69082820 (-)
AKR/J	ENSMUSG00220040277	protein coding gene	Chr6:68050467-68057193 (-)
BALB/cJ	ENSMUSG00180033574	protein coding gene	Chr6:69431029-69437788 (-)
C3H/HeJ	ENSMUSG00175011453	protein coding gene	Chr6:107982954-107989717 (+)
C57BL/6NJ	ENSMUSG00215041717	protein coding gene	Chr6:69403724-69410483 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028505	protein coding gene	Chr6:69302346-69308733 (-)
CAST/EiJ	ENSTCUG00005034202	protein coding gene	Chr6:69561510-69568262 (-)
CBA/J	ENSMUSG00210035174	protein coding gene	Chr6:69261019-69267782 (-)
DBA/2J	ENSMUSG00185039830	protein coding gene	Chr6:69821152-69827915 (-)
FVB/NJ	ENSMUSG00205027603	protein coding gene	Chr6:68526553-68533312 (-)
JF1/MsJ	ENSUMUG00000032357	protein coding gene	Chr6:68870149-68876874 (-)
LP/J	ENSMUSG00230020395	protein coding gene	Chr6:70908878-70915637 (-)
NOD/ShiLtJ	ENSMUSG00190029534	protein coding gene	Chr6:68789661-68796386 (-)
NZO/HlLtJ	ENSMUSG00225006611	protein coding gene	Chr6:72882727-72889486 (-)
PWK/PhJ	ENSLUMG00010018627	protein coding gene	Chr6:68280734-68287462 (-)
SPRET/EiJ	ENSMSPG00010023850	protein coding gene	Chr6:70106728-70113456 (-)
WSB/EiJ	ENSIUOG00005021900	protein coding gene	Chr6:69813904-69820647 (-)

Human Ortholog

MAT2A, methionine adenosyltransferase 2A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAT2A, methionine adenosyltransferase 2A
Synonyms

MATA2, MATII, SAMS2
Links

HGNC:6904

NCBI Gene ID: 4144

UniProt: P31153
Chr Location

2p11.2; chr2:85539165-85545281 (+) GRCh38

MGI Vertebrate Homology

Mat2a stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: MAT2A
Protein SuperFamily

MAT
Gene Tree

Mat2a

Diseases

1 with human MAT2A associations

				Human Disease	Mouse Models
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 NCI:C194105 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

5
Gene trapped

21
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Mat2a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

45
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

70
cDNA Data

18
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mat2a

ZFIN mat2aa, mat2ab

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All Sequences

125
RefSeq

6
UniProt

12
CCDS

CCDS39515.1, CCDS90059.1, CCDS90060.1

Ensembl

ENSMUSG00000053907 (Evidence)
NCBI Gene

232087

			Length	Strain/Species	Flank
genomic	ENSMUSG00000053907	Ensembl Gene Model \| MGI Sequence Detail	6760	C57BL/6J	± kb
transcript	ENSMUST00000059472	Ensembl \| MGI Sequence Detail	2804	Not Applicable
polypeptide	ENSMUSP00000087118	Ensembl \| MGI Sequence Detail	395	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000010202 S-adenosylmethionine synthetase isoform type-2

(term hierarchy)
EC

2.5.1.6
InterPro Domains

IPR002133 S-adenosylmethionine synthetase

IPR022629 S-adenosylmethionine synthetase, central domain

IPR022631 S-adenosylmethionine synthetase, conserved site

IPR022630 S-adenosylmethionine synthetase, C-terminal

IPR022628 S-adenosylmethionine synthetase, N-terminal

IPR022636 S-adenosylmethionine synthetase superfamily
GlyGen

Q3THS6 1 site, 1 O-linked glycan (1 site)

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All nucleic 24

cDNA 19

Primer pair 5

Antibodies 2

Microarray probesets 7

Summaries

All 67

Developmental Gene Expression 12

Gene Ontology 11

Phenotypes 23
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376

TSS for Mat2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61458	Chr6:72416532-72416547 (-)	1 bp
Tssr61457	Chr6:72414055-72414069 (-)	2,479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24