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Pou6f2 Gene Detail
Summary
  • Symbol
    Pou6f2
  • Name
    POU domain, class 6, transcription factor 2
  • Synonyms
    D130006K24Rik, RPF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443631
    NCBI Gene: 218030
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:18295683-18797700 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 6.05 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    13939 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443631
 protein coding gene Chr13:18295683-18797703 (-)
129S1/SvImJ ENSMUSG00200013830
 protein coding gene Chr13:15534450-15795837 (-)
A/J ENSMUSG00195034110
 protein coding gene Chr13:14645053-14906054 (-)
AKR/J ENSMUSG00220028946
 protein coding gene Chr13:14563816-14832205 (-)
BALB/cJ ENSMUSG00180032946
 protein coding gene Chr13:15000924-15261921 (-)
C3H/HeJ ENSMUSG00175028649
 protein coding gene Chr13:15101471-15362432 (-)
C57BL/6NJ ENSMUSG00215028153
 protein coding gene Chr13:15051960-15312926 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018249
 protein coding gene Chr13:13486651-13754563 (-)
CAST/EiJ ENSTCUG00005013814
 protein coding gene Chr13:15141255-15410054 (-)
CBA/J ENSMUSG00210029776
 protein coding gene Chr13:14961376-15222333 (-)
DBA/2J ENSMUSG00185012486
 protein coding gene Chr13:15662735-15923687 (-)
FVB/NJ ENSMUSG00205021474
 protein coding gene Chr13:14814454-15075367 (-)
JF1/MsJ ENSUMUG00000012907
 protein coding gene Chr13:15384797-15653359 (-)
LP/J ENSMUSG00230033811
 protein coding gene Chr13:25065147-25326103 (-)
NOD/ShiLtJ ENSMUSG00190018846
 protein coding gene Chr13:14925332-15186240 (-)
NZO/HlLtJ ENSMUSG00225032054
 protein coding gene Chr13:18814976-19075927 (-)
PWK/PhJ ENSLUMG00010025817
 protein coding gene Chr13:14365041-14632989 (-)
SPRET/EiJ ENSMSPG00010018251
 protein coding gene Chr13:14030268-14299984 (-)
WSB/EiJ ENSIUOG00005030871
 protein coding gene Chr13:14260306-14519134 (-)



Homology
more
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU6F2, POU class 6 homeobox 2
  • Synonyms
    RPF-1, WT5, WTSL
  • Links
    NCBI Gene ID: 11281
    UniProt: P78424

  • Chr Location
    7p14.1; chr7:38977909-39493095 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human POU6F2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Mice homozygous for a knock-out allele are viable, fertile and of normal size with no apparent phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    54
  • cDNA Data
    10
  • Literature Summary
    20
Sequences &
Gene Models
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  • All Sequences
    65
  • RefSeq
    19
  • UniProt
    7
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009734 Ensembl Gene Model | MGI Sequence Detail 502018 C57BL/6J ±  kb
transcript ENSMUST00000139064 Ensembl | MGI Sequence Detail 6296 Not Applicable  
polypeptide ENSMUSP00000114173 Ensembl | MGI Sequence Detail 728 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1
    Antibodies 2

    Microarray probesets 2
References
more
  • Summaries
    All 56
    Developmental Gene Expression 20
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:341711 Zhou H, et al., Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells. J Neurosci. 1996 Apr 1;16(7):2261-74
  • Latest
    J:382758 Segarra LC, et al., Evidence for chronological diversification of spinal neuron subtypes by a shared sequence of transcription factors. Sci Adv. 2026 Mar 20;12(12):eadz3075
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory