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Cemip Gene Detail
Summary
  • Symbol
    Cemip
  • Name
    cell migration inducing protein, hyaluronan binding
  • Synonyms
    12H19.01.T7, 6330404C01Rik, 9930013L23Rik, Hybid
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443629
    NCBI Gene: 80982
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:83582065-83735710 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 48.35 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4205 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443629
 protein coding gene Chr7:83582065-83735893 (-)
129S1/SvImJ ENSMUSG00200033787
 protein coding gene Chr7:70388314-70540829 (-)
A/J ENSMUSG00195040491
 protein coding gene Chr7:74847147-74998250 (-)
AKR/J ENSMUSG00220034593
 protein coding gene Chr7:68365355-68516466 (-)
BALB/cJ ENSMUSG00180034343
 protein coding gene Chr7:71552757-71703866 (-)
C3H/HeJ ENSMUSG00175033762
 protein coding gene Chr7:72300356-72452860 (-)
C57BL/6NJ ENSMUSG00215013933
 protein coding gene Chr7:71412732-71565293 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029945
 protein coding gene Chr7:86379734-86530349 (-)
CAST/EiJ ENSTCUG00005043930
 protein coding gene Chr7:74858316-75013676 (-)
CBA/J ENSMUSG00210039038
 protein coding gene Chr7:72162611-72315123 (-)
DBA/2J ENSMUSG00185045377
 protein coding gene Chr7:76474013-76626516 (-)
FVB/NJ ENSMUSG00205019577
 protein coding gene Chr7:72103533-72254646 (-)
JF1/MsJ ENSUMUG00000017429
 protein coding gene Chr7:81164762-81321995 (-)
LP/J ENSMUSG00230014908
 protein coding gene Chr7:82563411-82715914 (-)
NOD/ShiLtJ ENSMUSG00190023123
 protein coding gene Chr7:72309801-72460893 (-)
NZO/HlLtJ ENSMUSG00225010070
 protein coding gene Chr7:80838260-80990753 (-)
PWK/PhJ ENSLUMG00010033732
 protein coding gene Chr7:70755765-70911682 (-)
SPRET/EiJ ENSMSPG00010012318
 protein coding gene Chr7:71192952-71348924 (-)
WSB/EiJ ENSIUOG00005032130
 protein coding gene Chr7:72648392-72799605 (-)



Homology
more
  • Human Ortholog
    CEMIP, cell migration inducing hyaluronidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEMIP, cell migration inducing hyaluronidase 1
  • Synonyms
    CCSP1, CEMIP1, HYBID, KIAA1199, TMEM2L
  • Links
    NCBI Gene ID: 57214
    UniProt: Q8WUJ3

  • Chr Location
    15q25.1; chr15:80779343-80951776 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in Schwann cells exhibit transient acceleration of postnatal myelination, reduced demyelination in culture, and reduced myelin degradation and increases remyelination following nerve axotomy or sciatic nerve crush. Mice homozygous for a null allele exhibit incomplete prenatal lethality, decreased osteoclast cell number, decreased angiogenesis, increased long bone epiphyseal plate size, and short long bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    60
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    45
  • cDNA Data
    20
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052353 Ensembl Gene Model | MGI Sequence Detail 153646 C57BL/6J ±  kb
    transcript ENSMUST00000064174 Ensembl | MGI Sequence Detail 7111 Not Applicable  
    polypeptide ENSMUSP00000063277 Ensembl | MGI Sequence Detail 1361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917968, MGI:1931098
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 28
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:380148 Wakana S, et al., Delayed Bone Fracture Healing in Hybid (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization)-Deficient Mice. Am J Pathol. 2026 Mar;196(3):766-779
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory