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Pik3r5 Gene Detail
Summary
  • Symbol
    Pik3r5
  • Name
    phosphoinositide-3-kinase regulatory subunit 5
  • Synonyms
    Foap2, p101
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443588
    NCBI Gene: 320207
  • Alliance
    genome feature page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:68322951-68388675 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 41.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1983 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443588
 protein coding gene Chr11:68322947-68388675 (+)
129S1/SvImJ ENSMUSG00200048697
 protein coding gene Chr11:65265840-65331552 (+)
A/J ENSMUSG00195035940
 protein coding gene Chr11:65285322-65351030 (+)
AKR/J ENSMUSG00220054154
 protein coding gene Chr11:65401578-65467285 (+)
BALB/cJ ENSMUSG00180036442
 protein coding gene Chr11:65365915-65431652 (+)
C3H/HeJ ENSMUSG00175053145
 protein coding gene Chr11:65316259-65381991 (+)
C57BL/6NJ ENSMUSG00215050275
 protein coding gene Chr11:65091584-65157311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016536
 protein coding gene Chr11:63147878-63213708 (+)
CAST/EiJ ENSTCUG00005047270
 protein coding gene Chr11:64840723-64906535 (+)
CBA/J ENSMUSG00210051645
 protein coding gene Chr11:65170370-65236098 (+)
DBA/2J ENSMUSG00185052889
 protein coding gene Chr11:65364606-65430342 (+)
FVB/NJ ENSMUSG00205032419
 protein coding gene Chr11:65260426-65326169 (+)
JF1/MsJ ENSUMUG00000051489
 protein coding gene Chr11:65752517-65817935 (+)
LP/J ENSMUSG00230052728
 protein coding gene Chr11:66476245-66541952 (+)
NOD/ShiLtJ ENSMUSG00190054056
 protein coding gene Chr11:65398118-65463853 (+)
NZO/HlLtJ ENSMUSG00225047158
 protein coding gene Chr11:68653211-68718929 (+)
PWK/PhJ ENSLUMG00010053271
 protein coding gene Chr11:65293307-65337555 (+)
SPRET/EiJ ENSMSPG00010031411
 protein coding gene Chr11:66012681-66078054 (+)
WSB/EiJ ENSIUOG00005047439
 protein coding gene Chr11:65290598-65363291 (+)



Homology
more
  • Human Ortholog
    PIK3R5, phosphoinositide-3-kinase regulatory subunit 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3R5, phosphoinositide-3-kinase regulatory subunit 5
  • Synonyms
    F730038I15Rik, FOAP-2, p101, P101-PI3K
  • Links
    NCBI Gene ID: 23533
    UniProt: Q8WYR1

  • Chr Location
    17p13.1; chr17:8878911-8965726 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PIK3R5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit significantly reduced neutrophil chemotaxis and chemokinesis in vitro and impaired neutrophil recruitment into the peritoneum in a model of thioglycollate-induced aseptic peritonitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    24
  • cDNA Data
    31
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 320207 NCBI Gene Model | MGI Sequence Detail 65725 C57BL/6J ±  kb
transcript NM_177320 RefSeq | MGI Sequence Detail 4363 C57BL/6  
polypeptide Q5SW28 UniProt | EBI | MGI Sequence Detail 871 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000012728 phosphoinositide 3-kinase regulatory subunit 5
    (term hierarchy)
  • InterPro Domains
    IPR019522 Phosphoinositide 3-kinase regulatory subunit 5/6
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144465
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:342280 Rynkiewicz NK, et al., Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils. Sci Signal. 2020 Nov 3;13(656)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory