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Tmem74 Gene Detail
Summary
  • Symbol
    Tmem74
  • Name
    transmembrane protein 74
  • Synonyms
    B230382K22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443417
    NCBI Gene: 239408
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43728042-43733432 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.82 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    243 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443417
 protein coding gene Chr15:43726741-43733462 (-)
129S1/SvImJ ENSMUSG00200025319
 protein coding gene Chr15:40666028-40671478 (-)
A/J ENSMUSG00195005499
 protein coding gene Chr15:40663307-40668687 (-)
AKR/J ENSMUSG00220018041
 protein coding gene Chr15:40601258-40606660 (-)
BALB/cJ ENSMUSG00180004461
 protein coding gene Chr15:40648582-40653994 (-)
C3H/HeJ ENSMUSG00175019669
 protein coding gene Chr15:40858626-40864020 (-)
C57BL/6NJ ENSMUSG00215003222
 protein coding gene Chr15:40662382-40667792 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019770
 protein coding gene Chr15:38402721-38406023 (-)
CAST/EiJ ENSTCUG00005010595
 protein coding gene Chr15:40630610-40636044 (-)
CBA/J ENSMUSG00210026047
 protein coding gene Chr15:40779490-40784936 (-)
DBA/2J ENSMUSG00185012926
 protein coding gene Chr15:40745045-40750494 (-)
FVB/NJ ENSMUSG00205011835
 protein coding gene Chr15:40648405-40653799 (-)
JF1/MsJ ENSUMUG00000033713
 protein coding gene Chr15:40605201-40610597 (-)
LP/J ENSMUSG00230013778
 protein coding gene Chr15:44049730-44055186 (-)
NOD/ShiLtJ ENSMUSG00190008173
 protein coding gene Chr15:40716345-40721809 (-)
NZO/HlLtJ ENSMUSG00225037847
 protein coding gene Chr15:44423291-44428740 (-)
PWK/PhJ ENSLUMG00010029990
 protein coding gene Chr15:40784970-40790345 (-)
SPRET/EiJ ENSMSPG00010006562
 protein coding gene Chr15:41622405-41625719 (-)
WSB/EiJ ENSIUOG00005031265
 protein coding gene Chr15:40712758-40718188 (-)



Homology
more
  • Human Ortholog
    TMEM74, transmembrane protein 74
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM74, transmembrane protein 74
  • Synonyms
    NET36
  • Links
    NCBI Gene ID: 157753
    UniProt: Q96NL1

  • Chr Location
    8q23.1; chr8:108606850-108787624 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects basolateral amygdaloid nucleus (BLA) pyramidal neuron electrophysiology, leading to increased anxiety-like behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    599
  • Tissues
    2
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054409 Ensembl Gene Model | MGI Sequence Detail 5391 C57BL/6J ±  kb
    transcript ENSMUST00000067469 Ensembl | MGI Sequence Detail 3528 Not Applicable  
    polypeptide ENSMUSP00000070748 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3034807
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory