Tmem131l MGI Mouse Gene Detail - MGI:2443399

Symbol

Tmem131l
Name

transmembrane 131 like
Synonyms

D930015E06Rik, mKIAA0922

Feature Type

protein coding gene
IDs

MGI:2443399
NCBI Gene: 229473
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:83804962-83947482 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 37.42 cM
Mapping Data

1 experiment

SNPs within 2kb

914 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443399	protein coding gene	Chr3:83804962-83947497 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027338	protein coding gene	Chr3:83781863-83936413 (-)
A/J	MGP_AJ_G0027302	protein coding gene	Chr3:81012674-81154978 (-)
AKR/J	MGP_AKRJ_G0027268	protein coding gene	Chr3:82912090-83060841 (-)
BALB/cJ	MGP_BALBcJ_G0027311	protein coding gene	Chr3:81081395-81223143 (-)
C3H/HeJ	MGP_C3HHeJ_G0027055	protein coding gene	Chr3:83229258-83376781 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027757	protein coding gene	Chr3:86910035-87063175 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025110	protein coding gene	Chr3:76691477-76834278 (-)
CAST/EiJ	MGP_CASTEiJ_G0026502	protein coding gene	Chr3:83398498-83553960 (-)
CBA/J	MGP_CBAJ_G0027030	protein coding gene	Chr3:89847070-90003586 (-)
DBA/2J	MGP_DBA2J_G0027166	protein coding gene	Chr3:80529737-80673679 (-)
FVB/NJ	MGP_FVBNJ_G0027134	protein coding gene	Chr3:78817170-78963177 (-)
LP/J	MGP_LPJ_G0027274	protein coding gene	Chr3:84756770-84911496 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027153	protein coding gene	Chr3:96214141-96363917 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027815	protein coding gene	Chr3:82718561-82866953 (-)
PWK/PhJ	MGP_PWKPhJ_G0026236	protein coding gene	Chr3:80298479-80444053 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026052	protein coding gene	Chr3:81896489-82047299 (-)
WSB/EiJ	MGP_WSBEiJ_G0026580	protein coding gene	Chr3:83067395-83220151 (-)

Human Ortholog

TMEM131L, transmembrane 131 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM131L, transmembrane 131 like
Synonyms

KIAA0922
Links

HGNC:29146

NCBI Gene ID: 23240

neXtProt AC: NX_A2VDJ0

UniProt: A2VDJ0
Chr Location

4q31.3; chr4:153466346-153636711 (+) GRCh38

Alliance of Genome Resources

Tmem131l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM131L
Gene Tree

Tmem131l

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

20
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Tmem131l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

920
Tissues

143
cDNA Data

207
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem131l

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Tmem131l interacts with 51 markers (Mir23a, Mir23b, Mir30a, ...) View All

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All Sequences

82
RefSeq

18
UniProt

4
CCDS

CCDS38463.1

Ensembl

ENSMUSG00000033767 (Evidence)
NCBI Gene

229473

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033767	Ensembl Gene Model \| MGI Sequence Detail	142521	C57BL/6J	± kb
transcript	ENSMUST00000191758	Ensembl \| MGI Sequence Detail	5555	Not Applicable
polypeptide	ENSMUSP00000141438	Ensembl \| MGI Sequence Detail	1597	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000059682 transmembrane protein 131-like

(term hierarchy)
InterPro Domains

IPR013783 Immunoglobulin-like fold

IPR039877 Transmembrane protein 131-like

IPR045695 Transmembrane protein 131-like, conserved domain

IPR022113 Transmembrane protein 131-like, N-terminal

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All nucleic 209

cDNA 207

Primer pair 1

Other 1

Microarray probesets 5

Summaries

All 36

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 12
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Tmem131l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33844	Chr3:83947599-83947628 (-)	-132 bp
Tssr33843	Chr3:83947583-83947597 (-)	-108 bp
Tssr33842	Chr3:83947563-83947570 (-)	-85 bp
Tssr33841	Chr3:83947458-83947478 (-)	14 bp
Tssr33840	Chr3:83947407-83947454 (-)	51 bp
Tssr33839	Chr3:83947182-83947212 (-)	285 bp
Tssr33838	Chr3:83888203-83888208 (-)	59,276 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/12/2023 MGI 6.22