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Nudt15 Gene Detail
Summary
  • Symbol
    Nudt15
  • Name
    nudix hydrolase 15
  • Synonyms
    A730068G11Rik, MTH2, nudix (nucleoside diphosphate linked moiety X)-type motif 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443366
    NCBI Gene: 214254
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:73756320-73785682 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 39.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443366
protein coding gene Chr14:73756317-73785682 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021559
protein coding gene Chr14:68277055-68315584 (-)
A/J MGP_AJ_G0021518
protein coding gene Chr14:66778949-66807804 (-)
AKR/J MGP_AKRJ_G0021494
protein coding gene Chr14:68738039-68772455 (-)
BALB/cJ MGP_BALBcJ_G0021524
protein coding gene Chr14:66549687-66576037 (-)
C3H/HeJ MGP_C3HHeJ_G0021301
protein coding gene Chr14:68466684-68498429 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021965
protein coding gene Chr14:71273728-71310036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019503
protein coding gene Chr14:64495753-64533989 (-)
CAST/EiJ MGP_CASTEiJ_G0020819
protein coding gene Chr14:65137477-65168919 (-)
CBA/J MGP_CBAJ_G0021269
protein coding gene Chr14:73518554-73553831 (-)
DBA/2J MGP_DBA2J_G0021392
protein coding gene Chr14:66158244-66189034 (-)
FVB/NJ MGP_FVBNJ_G0021370
protein coding gene Chr14:65539671-65569272 (-)
LP/J MGP_LPJ_G0021462
protein coding gene Chr14:69439798-69477725 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024882
protein coding gene Chr19:34854701-34862771 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021988
protein coding gene Chr14:68019992-68055398 (-)
PWK/PhJ MGP_PWKPhJ_G0020562
protein coding gene Chr14:62941160-62973211 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020397
protein coding gene Chr14:63981951-64012813 (-)
WSB/EiJ MGP_WSBEiJ_G0020871
protein coding gene Chr14:68364963-68368107 (-)



Homology
more
  • Human Ortholog
    NUDT15, nudix hydrolase 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUDT15, nudix hydrolase 15
  • Synonyms
    MTH2, NUDT15D
  • Links
    NCBI Gene ID: 55270
    neXtProt AC: NX_Q9NV35
    UniProt: Q9NV35

  • Chr Location
    13q14.2; chr13:48037726-48052755 (+)  GRCh38

Human Diseases
more
  • Diseases
    3 with Nudt15 mouse models; 1 with human NUDT15 associations

Human Disease Mouse Models
      
IDs
View 2 models
IDs
View 2 models
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homo- or heterozygosity for the p.R138C mutation results in dose-dependent thiopurine-mediated pancytopenia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 214254 NCBI Gene Model | MGI Sequence Detail 29363 C57BL/6J ±  kb
transcript NM_172527 RefSeq | MGI Sequence Detail 3576 C57BL/6  
polypeptide Q8BG93 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Diseases 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:344719 Yamashita N, et al., Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells. Sci Rep. 2023 Jul 24;13(1):11908

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory