Tmem198 Gene Detail

Summary

• Symbol
  Tmem198
• Name
  transmembrane protein 198
• Synonyms
  A230078I05Rik, Tmem198-1, Tmem198a

• Feature Type
  protein coding gene
• IDs
  MGI:2443133
  NCBI Gene: 319998
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr1:75456176-75462349 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 1, 39.15 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  24 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443133	protein coding gene	Chr1:75456115-75462349 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016191	protein coding gene	Chr1:76057343-76063513 (+)
A/J	MGP_AJ_G0016174	protein coding gene	Chr1:73403618-73409791 (+)
AKR/J	MGP_AKRJ_G0016131	protein coding gene	Chr1:75437542-75443713 (+)
BALB/cJ	MGP_BALBcJ_G0016129	protein coding gene	Chr1:73466215-73472381 (+)
C3H/HeJ	MGP_C3HHeJ_G0015960	protein coding gene	Chr1:75770448-75776616 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016582	protein coding gene	Chr1:79011502-79017705 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014303	protein coding gene	Chr1:68962693-68968955 (+)
CAST/EiJ	MGP_CASTEiJ_G0015544	protein coding gene	Chr1:75115443-75121629 (+)
CBA/J	MGP_CBAJ_G0015933	protein coding gene	Chr1:81589023-81595087 (+)
DBA/2J	MGP_DBA2J_G0016034	protein coding gene	Chr1:72722954-72729124 (+)
FVB/NJ	MGP_FVBNJ_G0016037	protein coding gene	Chr1:71929117-71935288 (+)
LP/J	MGP_LPJ_G0016106	protein coding gene	Chr1:77184663-77190848 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016057	protein coding gene	Chr1:84923555-84929720 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016629	protein coding gene	Chr1:75507432-75513602 (+)
PWK/PhJ	MGP_PWKPhJ_G0015331	protein coding gene	Chr1:72199511-72205735 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015109	protein coding gene	Chr1:74863193-74869354 (+)
WSB/EiJ	MGP_WSBEiJ_G0015606	protein coding gene	Chr1:75317001-75323175 (+)

Homology

• Human Ortholog
  TMEM198, transmembrane protein 198

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TMEM198, transmembrane protein 198
  
• Synonyms
  TMEM198A
• Links
  HGNC:33704

  NCBI Gene ID: 130612

  neXtProt AC: NX_Q66K66

  UniProt: Q66K66

  
  
• Chr Location
  2q35; chr2:219543663-219550595 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tmem198 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: TMEM198
• Gene Tree
  Tmem198
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  22 phenotype references
  

• All Mutations and Alleles
  8
• Chemically induced (other)
  1
• Endonuclease-mediated
  2
• Radiation induced
  2
• Spontaneous
  1
• Targeted
  2
• Genomic Mutations
  4 involving Tmem198
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  16 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  7
• GO References
  3

Expression

• Assay Results
  736
• Tissues
  2
• cDNA Data
  16
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase tmem198
  ZFIN tmem198b

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  4
• UniProt
  3
• CCDS
  CCDS15076.1

• Ensembl
  ENSMUSG00000051703 (Evidence)
• NCBI Gene
  319998

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000051703	Ensembl Gene Model | MGI Sequence Detail	6174	C57BL/6J
transcript	ENSMUST00000050899	Ensembl | MGI Sequence Detail	2456	Not Applicable
polypeptide	ENSMUSP00000057865	Ensembl | MGI Sequence Detail	360	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000032609 transmembrane protein 198
  (term hierarchy)
• InterPro Domains
  IPR025256 Domain of unknown function DUF4203
  IPR040236 Transmembrane protein 198

Molecular
Reagents

• All nucleic 16

  cDNA 16

  
  

  Microarray probesets 3

References

• Summaries
  All 43

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 3

  Phenotypes 22
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Tmem198:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7538	Chr1:75456150-75456161 (+)	-20 bp
Tssr7539	Chr1:75456173-75456237 (+)	29 bp