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Lrp12 Gene Detail
Summary
  • Symbol
    Lrp12
  • Name
    low density lipoprotein-related protein 12
  • Synonyms
    C820005L12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443132
    NCBI Gene: 239393
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:39733985-39807390 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.59 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    635 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443132
protein coding gene Chr15:39733985-39807417 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021818
protein coding gene Chr15:38332282-38406977 (-)
A/J MGP_AJ_G0021778
protein coding gene Chr15:36828231-36907455 (-)
AKR/J MGP_AKRJ_G0021759
protein coding gene Chr15:37926373-38001122 (-)
BALB/cJ MGP_BALBcJ_G0021785
protein coding gene Chr15:36892291-36965522 (-)
C3H/HeJ MGP_C3HHeJ_G0021559
protein coding gene Chr15:37854181-37933609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022224
protein coding gene Chr15:39787909-39873714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019761
protein coding gene Chr15:34587021-34660402 (-)
CAST/EiJ MGP_CASTEiJ_G0021076
protein coding gene Chr15:38312089-38391381 (-)
CBA/J MGP_CBAJ_G0021528
protein coding gene Chr15:41213637-41287330 (-)
DBA/2J MGP_DBA2J_G0021652
protein coding gene Chr15:36678115-36754617 (-)
FVB/NJ MGP_FVBNJ_G0021630
protein coding gene Chr15:36057169-36131902 (-)
LP/J MGP_LPJ_G0021722
protein coding gene Chr15:38142798-38215963 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021654
protein coding gene Chr15:44200619-44276306 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022247
protein coding gene Chr15:38102129-38176365 (-)
PWK/PhJ MGP_PWKPhJ_G0020821
protein coding gene Chr15:36734067-36806653 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020658
protein coding gene Chr15:37762391-37836247 (-)
WSB/EiJ MGP_WSBEiJ_G0021131
protein coding gene Chr15:38006942-38088875 (-)



Homology
more
  • Human Ortholog
    LRP12, LDL receptor related protein 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRP12, LDL receptor related protein 12
  • Synonyms
    ALS28, MIG13A, ST7
  • Links
    NCBI Gene ID: 29967
    neXtProt AC: NX_Q9Y561
    UniProt: Q9Y561

  • Chr Location
    8q22.3; chr8:104489231-104589258 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human LRP12 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022305 Ensembl Gene Model | MGI Sequence Detail 73406 C57BL/6J ±  kb
    transcript ENSMUST00000022916 Ensembl | MGI Sequence Detail 4109 Not Applicable  
    polypeptide ENSMUSP00000022916 Ensembl | MGI Sequence Detail 858 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000009919 low-density lipoprotein receptor-related protein 12
    • InterPro Domains
      IPR000859 CUB domain
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR035914 Spermadhesin, CUB domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 33

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146083
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:338432 Huang M, et al., LRP12 is an endogenous transmembrane inactivator of alpha4 integrins. Cell Rep. 2023 Jun 17;42(6):112667

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory