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Brinp3 Gene Detail
Summary
  • Symbol
    Brinp3
  • Name
    bone morphogenetic protein/retinoic acid inducible neural specific 3
  • Synonyms
    B830045N13Rik, Fam5c
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443035
    NCBI Gene: 215378
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:146371367-146778210 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 63.24 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3045 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443035
protein coding gene Chr1:146370498-146778210 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016570
protein coding gene Chr1:150956308-151383959 (+)
A/J MGP_AJ_G0016553
protein coding gene Chr1:144881511-145287902 (+)
AKR/J MGP_AKRJ_G0016518
protein coding gene Chr1:149355514-149780198 (+)
BALB/cJ MGP_BALBcJ_G0016513
protein coding gene Chr1:145370074-145790303 (+)
C3H/HeJ MGP_C3HHeJ_G0016338
protein coding gene Chr1:149473466-149930618 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016974
protein coding gene Chr1:156050322-156533337 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014683
protein coding gene Chr1:137514006-137877558 (+)
CAST/EiJ MGP_CASTEiJ_G0015917
protein coding gene Chr1:148905562-149348841 (+)
CBA/J MGP_CBAJ_G0016312
protein coding gene Chr1:161594143-162070309 (+)
DBA/2J MGP_DBA2J_G0016418
protein coding gene Chr1:143997622-144399978 (+)
FVB/NJ MGP_FVBNJ_G0016416
protein coding gene Chr1:142441763-142855952 (+)
LP/J MGP_LPJ_G0016489
protein coding gene Chr1:151923177-152358048 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016442
protein coding gene Chr1:168497364-169085512 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017010
protein coding gene Chr1:149081577-149520387 (+)
PWK/PhJ MGP_PWKPhJ_G0015703
protein coding gene Chr1:142869222-143291909 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015490
protein coding gene Chr1:147837968-148234881 (+)
WSB/EiJ MGP_WSBEiJ_G0015980
protein coding gene Chr1:149196704-149629388 (+)



Homology
more
  • Human Ortholog
    BRINP3, BMP/retinoic acid inducible neural specific 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRINP3, BMP/retinoic acid inducible neural specific 3
  • Synonyms
    DBCCR1L, DBCCR1L1, FAM5C
  • Links
    NCBI Gene ID: 339479
    neXtProt AC: NX_Q76B58
    UniProt: Q76B58

  • Chr Location
    1q31.1; chr1:190097658-190478404 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with human BRINP3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 215378 NCBI Gene Model | MGI Sequence Detail 406844 C57BL/6J ±  kb
    transcript NM_001357571 RefSeq | MGI Sequence Detail 3227 ZRU/MplStud  
    polypeptide Q499E0 UniProt | EBI | MGI Sequence Detail 766 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000031555 BMP/retinoic acid-inducible neural-specific protein 3
    • InterPro Domains
      IPR033237 BMP/retinoic acid-inducible neural-specific protein
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR020864 Membrane attack complex component/perforin (MACPF) domain
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:244509 Berkowicz SR, et al., Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders. Front Behav Neurosci. 2016;10:196

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    02/20/2024
    MGI 6.23
    The Jackson Laboratory