Brinp3 MGI Mouse Gene Detail - MGI:2443035 - bone morphogenetic protein/retinoic acid inducible neural specific 3

Symbol

Brinp3
Name

bone morphogenetic protein/retinoic acid inducible neural specific 3
Synonyms

B830045N13Rik, Fam5c

Feature Type

protein coding gene
IDs

MGI:2443035
NCBI Gene: 215378
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:146371367-146778210 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 63.24 cM
Mapping Data

4 experiments

SNPs within 2kb

3045 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443035	protein coding gene	Chr1:146370498-146778210 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016570	protein coding gene	Chr1:150956308-151383959 (+)
A/J	MGP_AJ_G0016553	protein coding gene	Chr1:144881511-145287902 (+)
AKR/J	MGP_AKRJ_G0016518	protein coding gene	Chr1:149355514-149780198 (+)
BALB/cJ	MGP_BALBcJ_G0016513	protein coding gene	Chr1:145370074-145790303 (+)
C3H/HeJ	MGP_C3HHeJ_G0016338	protein coding gene	Chr1:149473466-149930618 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016974	protein coding gene	Chr1:156050322-156533337 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014683	protein coding gene	Chr1:137514006-137877558 (+)
CAST/EiJ	MGP_CASTEiJ_G0015917	protein coding gene	Chr1:148905562-149348841 (+)
CBA/J	MGP_CBAJ_G0016312	protein coding gene	Chr1:161594143-162070309 (+)
DBA/2J	MGP_DBA2J_G0016418	protein coding gene	Chr1:143997622-144399978 (+)
FVB/NJ	MGP_FVBNJ_G0016416	protein coding gene	Chr1:142441763-142855952 (+)
LP/J	MGP_LPJ_G0016489	protein coding gene	Chr1:151923177-152358048 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016442	protein coding gene	Chr1:168497364-169085512 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017010	protein coding gene	Chr1:149081577-149520387 (+)
PWK/PhJ	MGP_PWKPhJ_G0015703	protein coding gene	Chr1:142869222-143291909 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015490	protein coding gene	Chr1:147837968-148234881 (+)
WSB/EiJ	MGP_WSBEiJ_G0015980	protein coding gene	Chr1:149196704-149629388 (+)

Human Ortholog

BRINP3, BMP/retinoic acid inducible neural specific 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BRINP3, BMP/retinoic acid inducible neural specific 3
Synonyms

DBCCR1L, DBCCR1L1, FAM5C
Links

HGNC:22393

NCBI Gene ID: 339479

neXtProt AC: NX_Q76B58

UniProt: Q76B58
Chr Location

1q31.1; chr1:190097658-190478404 (-) GRCh38

MGI Vertebrate Homology

Brinp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BRINP3
Gene Tree

Brinp3

Diseases

2 with human BRINP3 associations

				Human Disease	Mouse Models
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

2 involving Brinp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

8
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase brinp3

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All Sequences

62
RefSeq

18
UniProt

4
CCDS

CCDS15351.1

Ensembl

ENSMUSG00000035131 (Evidence)
NCBI Gene

215378

			Length	Strain/Species	Flank
genomic	215378	NCBI Gene Model \| MGI Sequence Detail	406844	C57BL/6J	± kb
transcript	NM_001357571	RefSeq \| MGI Sequence Detail	3227	ZRU/MplStud
polypeptide	Q499E0	UniProt \| EBI \| MGI Sequence Detail	766	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031555 BMP/retinoic acid-inducible neural-specific protein 3

(term hierarchy)
InterPro Domains

IPR033237 BMP/retinoic acid-inducible neural-specific protein

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR020864 Membrane attack complex component/perforin (MACPF) domain

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 7
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:244509 Berkowicz SR, et al., Mice Lacking Brinp2 or Brinp3, or Both, Exhibit Behaviors Consistent with Neurodevelopmental Disorders. Front Behav Neurosci. 2016;10:196

TSS for Brinp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9214	Chr1:146371337-146371344 (+)	-26 bp
Tssr9215	Chr1:146371359-146371374 (+)	0 bp
Tssr9216	Chr1:146371382-146371417 (+)	33 bp
Tssr9217	Chr1:146371425-146371431 (+)	61 bp
Tssr9218	Chr1:146371436-146371445 (+)	74 bp
Tssr9219	Chr1:146373409-146373445 (+)	2,060 bp
Tssr9220	Chr1:146649924-146649934 (+)	278,562 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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