Sun2 MGI Mouse Gene Detail - MGI:2443011 - Sad1 and UNC84 domain containing 2

Symbol

Sun2
Name

Sad1 and UNC84 domain containing 2
Synonyms

B230369L08Rik, Unc84b

Feature Type

protein coding gene
IDs

MGI:2443011
NCBI Gene: 223697
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr15:79608271-79626737 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.85 cM
Mapping Data

2 experiments

SNPs within 2kb

496 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2443011	protein coding gene	Chr15:79608269-79626757 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022084	protein coding gene	Chr15:80017866-80035600 (-)
A/J	MGP_AJ_G0022045	protein coding gene	Chr15:77248575-77266421 (-)
AKR/J	MGP_AKRJ_G0022020	protein coding gene	Chr15:79411246-79429092 (-)
BALB/cJ	MGP_BALBcJ_G0022051	protein coding gene	Chr15:77261238-77279976 (-)
C3H/HeJ	MGP_C3HHeJ_G0021822	protein coding gene	Chr15:79397402-79416504 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022494	protein coding gene	Chr15:83166682-83185768 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020024	protein coding gene	Chr15:73731118-73749246 (-)
CAST/EiJ	MGP_CASTEiJ_G0021343	protein coding gene	Chr15:80110108-80127913 (-)
CBA/J	MGP_CBAJ_G0021787	protein coding gene	Chr15:85755963-85778131 (-)
DBA/2J	MGP_DBA2J_G0021916	protein coding gene	Chr15:76735418-76753316 (-)
FVB/NJ	MGP_FVBNJ_G0021894	protein coding gene	Chr15:75763237-75781951 (-)
LP/J	MGP_LPJ_G0021984	protein coding gene	Chr15:80206281-80227453 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021914	protein coding gene	Chr15:90855714-90875015 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022508	protein coding gene	Chr15:79431817-79450697 (-)
PWK/PhJ	MGP_PWKPhJ_G0021085	protein coding gene	Chr15:76746402-76764779 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020922	protein coding gene	Chr15:79229752-79251070 (-)
WSB/EiJ	MGP_WSBEiJ_G0021395	protein coding gene	Chr15:79816311-79835136 (-)

Human Ortholog

SUN2, Sad1 and UNC84 domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SUN2, Sad1 and UNC84 domain containing 2
Synonyms

rab5IP, UNC84B
Links

HGNC:14210

NCBI Gene ID: 25777

UniProt: Q9UH99
Chr Location

22q13.1; chr22:38733290-38794143 (-) GRCh38

MGI Vertebrate Homology

Sun2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SUN2
Gene Tree

Sun2

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 3 alleles in 3 genetic backgrounds
22 phenotypes from multigenic genotypes
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

2
Targeted

5
Genomic Mutations

3 involving Sun2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available

Mice homozygous for a null allele exhibit no gross abnormalities.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

45
cDNA Data

65
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sun2

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All Sequences

71
RefSeq

12
UniProt

5
CCDS

CCDS27649.1, CCDS56992.1, CCDS56993.1

Ensembl

ENSMUSG00000042524 (Evidence)
NCBI Gene

223697

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042524	Ensembl Gene Model \| MGI Sequence Detail	18467	C57BL/6J	± kb
transcript	ENSMUST00000046259	Ensembl \| MGI Sequence Detail	3804	Not Applicable
polypeptide	ENSMUSP00000047864	Ensembl \| MGI Sequence Detail	731	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017100 SUN domain-containing protein 2

(term hierarchy)
PDB

5ED8, 5ED9
InterPro Domains

IPR040994 SUN coiled coil domain 2

IPR012919 SUN domain

IPR045119 SUN domain-containing protein 1-5
GlyGen

Q8BJS4 2 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (1 site)

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All nucleic 68

cDNA 65

Primer pair 3

Microarray probesets 3

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MGI:2146038

Summaries

All 85

Developmental Gene Expression 9

Diseases 1

Gene Ontology 6

Phenotypes 45
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:351152 Huang Y, et al., Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1. Nat Commun. 2024 Jan 5;15(1):296

TSS for Sun2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135379	Chr15:79626719-79626763 (-)	-4 bp
Tssr135378	Chr15:79626694-79626712 (-)	34 bp
Tssr135377	Chr15:79626666-79626677 (-)	65 bp
Tssr135376	Chr15:79625554-79625562 (-)	1,179 bp
Tssr135375	Chr15:79625529-79625542 (-)	1,201 bp
Tssr135374	Chr15:79625502-79625516 (-)	1,228 bp
Tssr135373	Chr15:79625482-79625498 (-)	1,247 bp
Tssr135372	Chr15:79623685-79623703 (-)	3,043 bp
Tssr135371	Chr15:79623207-79623219 (-)	3,524 bp
Tssr135370	Chr15:79620170-79620185 (-)	6,559 bp
Tssr135369	Chr15:79618566-79618602 (-)	8,153 bp
Tssr135368	Chr15:79617951-79617961 (-)	8,781 bp
Tssr135367	Chr15:79613325-79613334 (-)	13,407 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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