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Arglu1 Gene Detail
Summary
  • Symbol
    Arglu1
  • Name
    arginine and glutamate rich 1
  • Synonyms
    9430010O03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442985
    NCBI Gene: 234023
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:8715075-8740521 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 3.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    78 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442985
 protein coding gene Chr8:8715075-8741818 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033343
 protein coding gene Chr8:5739521-5763463 (-)
A/J MGP_AJ_G0033323
 protein coding gene Chr8:5554865-5578809 (-)
AKR/J MGP_AKRJ_G0033255
 protein coding gene Chr8:5735538-5759491 (-)
BALB/cJ MGP_BALBcJ_G0033324
 protein coding gene Chr8:5690855-5715182 (-)
C3H/HeJ MGP_C3HHeJ_G0033038
 protein coding gene Chr8:5890608-5917420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033836
 protein coding gene Chr8:6012446-6037106 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030807
 protein coding gene Chr8:5147037-5171925 (-)
CAST/EiJ MGP_CASTEiJ_G0032360
 protein coding gene Chr8:5556843-5582205 (-)
CBA/J MGP_CBAJ_G0033011
 protein coding gene Chr8:6271801-6297581 (-)
DBA/2J MGP_DBA2J_G0033164
 protein coding gene Chr8:5565047-5589380 (-)
FVB/NJ MGP_FVBNJ_G0033112
 protein coding gene Chr8:5507887-5531821 (-)
LP/J MGP_LPJ_G0033258
 protein coding gene Chr8:5647382-5673412 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033147
 protein coding gene Chr8:6695183-6719158 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033853
 protein coding gene Chr8:5727878-5751804 (-)
PWK/PhJ MGP_PWKPhJ_G0032073
 protein coding gene Chr8:5496772-5521836 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031915
 protein coding gene Chr8:5619782-5642911 (-)
WSB/EiJ MGP_WSBEiJ_G0032476
 protein coding gene Chr8:5785806-5810660 (-)



Homology
more
  • Human Ortholog
    ARGLU1, arginine and glutamate rich 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARGLU1, arginine and glutamate rich 1
  • Links
    NCBI Gene ID: 55082
    neXtProt AC: NX_Q9NWB6
    UniProt: Q9NWB6

  • Chr Location
    13q33.3; chr13:106541673-106568137 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic growth retardation, increased brain apoptosis, and complete embryonic lethality during organogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    55
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040459 Ensembl Gene Model | MGI Sequence Detail 25447 C57BL/6J ±  kb
    transcript ENSMUST00000048545 Ensembl | MGI Sequence Detail 3197 Not Applicable  
    polypeptide ENSMUSP00000039493 Ensembl | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:339368 Yao F, et al., Deletion of ARGLU1 causes global defects in alternative splicing in vivo and mouse cortical malformations primarily via apoptosis. Cell Death Dis. 2023 Aug 23;14(8):543
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory