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Mettl14 Gene Detail
Summary
  • Symbol
    Mettl14
  • Name
    methyltransferase 14, N6-adenosine-methyltransferase subunit
  • Synonyms
    G430022H21Rik, mKIAA1627
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442926
    NCBI Gene: 210529
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:123161944-123179639 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 53.96 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    593 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442926
 protein coding gene Chr3:123161944-123179757 (-)
129S1/SvImJ ENSMUSG00200023985
 protein coding gene Chr3:119852340-119870152 (-)
A/J ENSMUSG00195014633
 protein coding gene Chr3:120063459-120081196 (-)
AKR/J ENSMUSG00220024432
 protein coding gene Chr3:118456184-118473997 (-)
BALB/cJ ENSMUSG00180028375
 protein coding gene Chr3:120000204-120017940 (-)
C3H/HeJ ENSMUSG00175026235
 protein coding gene Chr3:119546708-119564444 (-)
C57BL/6NJ ENSMUSG00215006076
 protein coding gene Chr3:120302073-120319886 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025602
 protein coding gene Chr3:116890907-116908261 (-)
CAST/EiJ ENSTCUG00005030899
 protein coding gene Chr3:120594233-120611685 (-)
CBA/J ENSMUSG00210002714
 protein coding gene Chr3:120177586-120195320 (-)
DBA/2J ENSMUSG00185006908
 protein coding gene Chr3:120738206-120755940 (-)
FVB/NJ ENSMUSG00205006843
 protein coding gene Chr3:119117135-119134947 (-)
JF1/MsJ ENSUMUG00000002863
 protein coding gene Chr3:119544057-119561791 (-)
LP/J ENSMUSG00230003813
 protein coding gene Chr3:122704048-122721859 (-)
NOD/ShiLtJ ENSMUSG00190027996
 protein coding gene Chr3:121131105-121148916 (-)
NZO/HlLtJ ENSMUSG00225002546
 protein coding gene Chr3:125190048-125207859 (-)
PWK/PhJ ENSLUMG00010008971
 protein coding gene Chr3:119561221-119577766 (-)
SPRET/EiJ ENSMSPG00010029221
 protein coding gene Chr3:120303370-120318741 (-)
WSB/EiJ ENSIUOG00005006261
 protein coding gene Chr3:120363279-120381033 (-)



Homology
more
  • Human Ortholog
    METTL14, methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    METTL14, methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit
  • Synonyms
    hMETTL14
  • Links
    NCBI Gene ID: 57721
    UniProt: Q9HCE5

  • Chr Location
    4q26; chr4:118685387-118715433 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    16 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality and decreased histone acetylation. Mice homozygous for a conditional allele activated in neuronal stem cells exhibit decreased NSC proliferation and premature differentiation and decreased number of late-born neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    673
  • Tissues
    19
  • cDNA Data
    44
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 210529 NCBI Gene Model | MGI Sequence Detail 17696 C57BL/6J ±  kb
    transcript NM_201638 RefSeq | MGI Sequence Detail 2625 Not Specified  
    polypeptide Q3UIK4 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000031401 N(6)-adenosine-methyltransferase non-catalytic subunit METTL14
      (term hierarchy)
    • InterPro Domains
      IPR007757 MT-A70-like
      IPR045123 N6-adenosine-methyltransferase non-catalytic subunit METTL14-like
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 3
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 14
      Phenotypes 59
    • Earliest
      J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
    • Latest
      J:392282 Kim GD, et al., Dysregulated m(6)A via compensatory arginine methylation primes premalignancy in metabolic dysfunction-associated steatotic liver disease. Sci Adv. 2026 Sep 11;12(37):eaec5094
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory