Rabl6 MGI Mouse Gene Detail - MGI:2442633 - RAB, member RAS oncogene family-like 6

Symbol

Rabl6
Name

RAB, member RAS oncogene family-like 6
Synonyms

B230208H17Rik, Rbel1, Rbel1a, Rbel1b

Feature Type

protein coding gene
IDs

MGI:2442633
NCBI Gene: 227624
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:25473029-25498493 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.46 cM
Mapping Data

1 experiment

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442633	protein coding gene	Chr2:25473029-25498533 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025458	protein coding gene	Chr2:23485826-23517500 (-)
A/J	MGP_AJ_G0025435	protein coding gene	Chr2:22571428-22598034 (-)
AKR/J	MGP_AKRJ_G0025405	protein coding gene	Chr2:23340144-23365654 (-)
BALB/cJ	MGP_BALBcJ_G0025431	protein coding gene	Chr2:22692238-22717915 (-)
C3H/HeJ	MGP_C3HHeJ_G0025192	protein coding gene	Chr2:23270842-23298677 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025875	protein coding gene	Chr2:24224481-24255136 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023286	protein coding gene	Chr2:21482190-21507416 (-)
CAST/EiJ	MGP_CASTEiJ_G0024655	protein coding gene	Chr2:23137807-23164965 (-)
CBA/J	MGP_CBAJ_G0025170	protein coding gene	Chr2:25065111-25093283 (-)
DBA/2J	MGP_DBA2J_G0025303	protein coding gene	Chr2:22412509-22444939 (-)
FVB/NJ	MGP_FVBNJ_G0025265	protein coding gene	Chr2:22165233-22192351 (-)
LP/J	MGP_LPJ_G0025389	protein coding gene	Chr2:23423324-23450082 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025296	protein coding gene	Chr2:25258109-25285984 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025934	protein coding gene	Chr2:23280971-23313691 (-)
PWK/PhJ	MGP_PWKPhJ_G0024403	protein coding gene	Chr2:22233302-22258971 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024203	protein coding gene	Chr2:23424285-23451092 (-)
WSB/EiJ	MGP_WSBEiJ_G0024724	protein coding gene	Chr2:23351221-23378883 (-)

Human Ortholog

RABL6, RAB, member RAS oncogene family like 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RABL6, RAB, member RAS oncogene family like 6
Synonyms

C9orf86, PARF, pp8875, RBEL1
Links

HGNC:24703

NCBI Gene ID: 55684

neXtProt AC: NX_Q3YEC7

UniProt: Q3YEC7
Chr Location

9q34.3; chr9:136807943-136841187 (+) GRCh38

MGI Vertebrate Homology

Rabl6 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RABL6
Gene Tree

Rabl6

less

Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

931
Tissues

52
cDNA Data

14
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rabl6

ZFIN rabl6a

less

All Sequences

62
RefSeq

2
UniProt

1
CCDS

CCDS38076.1

Ensembl

ENSMUSG00000015087 (Evidence)
NCBI Gene

227624

			Length	Strain/Species	Flank
genomic	227624	NCBI Gene Model \| MGI Sequence Detail	25465	C57BL/6J	± kb
transcript	NM_001024616	RefSeq \| MGI Sequence Detail	3191	C57BL/6
polypeptide	Q5U3K5	UniProt \| EBI \| MGI Sequence Detail	725	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000031952 Rab-like protein 6

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR040385 Rab-like protein 6

less

All nucleic 14

cDNA 14

Microarray probesets 5

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 10
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:307908 Maharjan CK, et al., RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo. Biomedicines. 2021 Jun 2;9(6)

TSS for Rabl6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23035	Chr2:25498459-25498498 (-)	14 bp
Tssr23034	Chr2:25498433-25498444 (-)	54 bp
Tssr23033	Chr2:25497941-25497944 (-)	550 bp
Tssr23032	Chr2:25477589-25477619 (-)	20,889 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23