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Adamts18 Gene Detail
Summary
  • Symbol
    Adamts18
  • Name
    ADAM metallopeptidase with thrombospondin type 1 motif 18
  • Synonyms
    E130314N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442600
    NCBI Gene: 208936
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:114423758-114575370 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 59.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4861 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442600
 protein coding gene Chr8:114423755-114575975 (-)
129S1/SvImJ ENSMUSG00200014245
 protein coding gene Chr8:108762541-108913850 (-)
A/J ENSMUSG00195019327
 protein coding gene Chr8:109042798-109194382 (-)
AKR/J ENSMUSG00220014285
 protein coding gene Chr8:109228398-109379986 (-)
BALB/cJ ENSMUSG00180017548
 protein coding gene Chr8:109084072-109236360 (-)
C3H/HeJ ENSMUSG00175022079
 protein coding gene Chr8:109141113-109292686 (-)
C57BL/6NJ ENSMUSG00215032009
 protein coding gene Chr8:108713629-108865131 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031593
 protein coding gene Chr8:104881937-105032862 (-)
CAST/EiJ ENSTCUG00005033439
 protein coding gene Chr8:108456424-108607929 (-)
CBA/J ENSMUSG00210029710
 protein coding gene Chr8:109042462-109194024 (-)
DBA/2J ENSMUSG00185016694
 protein coding gene Chr8:115141402-115292976 (-)
FVB/NJ ENSMUSG00205015168
 protein coding gene Chr8:108055325-108206862 (-)
JF1/MsJ ENSUMUG00000014926
 protein coding gene Chr8:117473602-117625171 (-)
LP/J ENSMUSG00230033147
 protein coding gene Chr8:118819895-118971191 (-)
NOD/ShiLtJ ENSMUSG00190018651
 protein coding gene Chr8:109182254-109333779 (-)
NZO/HlLtJ ENSMUSG00225042046
 protein coding gene Chr8:122170661-122322144 (-)
PWK/PhJ ENSLUMG00010026345
 protein coding gene Chr8:108946078-109098945 (-)
SPRET/EiJ ENSMSPG00010037076
 protein coding gene Chr8:111070161-111239283 (-)
WSB/EiJ ENSIUOG00005027848
 protein coding gene Chr8:109903471-110054924 (-)



Homology
more
  • Human Ortholog
    ADAMTS18, ADAM metallopeptidase with thrombospondin type 1 motif 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAMTS18, ADAM metallopeptidase with thrombospondin type 1 motif 18
  • Synonyms
    ADAMTS21, KNO2, MMCAT
  • Links
    NCBI Gene ID: 170692
    UniProt: Q8TE60

  • Chr Location
    16q23.1; chr16:77247813-77435034 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele exhibit some fertility defects. Mice homozygous for a null allele exhibit growth and eye defects and increased susceptibility to chemically induced tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    91
  • cDNA Data
    36
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053399 Ensembl Gene Model | MGI Sequence Detail 151613 C57BL/6J ±  kb
    transcript ENSMUST00000093113 Ensembl | MGI Sequence Detail 5642 Not Applicable  
    polypeptide ENSMUSP00000090801 Ensembl | MGI Sequence Detail 1219 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 36
      Primer pair 7
      Other 5
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 20
      Gene Ontology 7
      Phenotypes 27
    • Earliest
      J:28082 Holmberg M, et al., The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters. Eur J Biochem. 1995 Jul 15;231(2):466-74
    • Latest
      J:361964 Wang M, et al., The secreted protease ADAMTS18 links early isoform transformation and maturation of glomerular basement membrane macromolecules to the integrity of the glomerular filtration barrier. Biochem Biophys Res Commun. 2025 Mar 1;750:151386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory