Dars1 MGI Mouse Gene Detail - MGI:2442544 - aspartyl-tRNA synthetase 1

Symbol

Dars1
Name

aspartyl-tRNA synthetase 1
Synonyms

5730439G15Rik, Dars

Feature Type

protein coding gene
IDs

MGI:2442544
NCBI Gene: 226414
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr1:128291444-128345105 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 55.80 cM
Mapping Data

1 experiment

SNPs within 2kb

1295 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442544	protein coding gene	Chr1:128291444-128345153 (-)
129S1/SvImJ	ENSMUSG00200008716	protein coding gene	Chr1:125844962-125898586 (-)
A/J	ENSMUSG00195038911	protein coding gene	Chr1:124930250-124983927 (-)
AKR/J	ENSMUSG00220047957	protein coding gene	Chr1:124781385-124835004 (-)
BALB/cJ	ENSMUSG00180036144	protein coding gene	Chr1:125499187-125552812 (-)
C3H/HeJ	ENSMUSG00175042932	protein coding gene	Chr1:125198892-125252578 (-)
C57BL/6NJ	ENSMUSG00215042999	protein coding gene	Chr1:125212997-125266664 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014547	protein coding gene	Chr1:120054683-120107255 (-)
CAST/EiJ	ENSTCUG00005030712	protein coding gene	Chr1:124133844-124187475 (-)
CBA/J	ENSMUSG00210025928	protein coding gene	Chr1:125079160-125132827 (-)
DBA/2J	ENSMUSG00185001958	protein coding gene	Chr1:129443341-129496961 (-)
FVB/NJ	ENSMUSG00205029230	protein coding gene	Chr1:124403616-124457244 (-)
JF1/MsJ	ENSUMUG00000001195	protein coding gene	Chr1:128571191-128624943 (-)
LP/J	ENSMUSG00230001036	protein coding gene	Chr1:129023304-129076916 (-)
NOD/ShiLtJ	ENSMUSG00190033120	protein coding gene	Chr1:125082310-125135979 (-)
NZO/HlLtJ	ENSMUSG00225004753	protein coding gene	Chr1:132759669-132813316 (-)
PWK/PhJ	ENSLUMG00010023306	protein coding gene	Chr1:124203868-124257507 (-)
SPRET/EiJ	ENSMSPG00010039783	protein coding gene	Chr1:126973035-127027162 (-)
WSB/EiJ	ENSIUOG00005041215	protein coding gene	Chr1:124802852-124856455 (-)

Human Ortholog

DARS1, aspartyl-tRNA synthetase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DARS1, aspartyl-tRNA synthetase 1
Synonyms

aspRS, DARS, HBSL
Links

HGNC:2678

NCBI Gene ID: 1615

UniProt: P14868
Chr Location

2q21.3; chr2:135905881-135986100 (-) GRCh38

MGI Vertebrate Homology

Dars1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DARS1
Gene Tree

Dars1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

67
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

57
Radiation induced

1
Genomic Mutations

3 involving Dars1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

69 strains or lines available

Mice homozygous for a knock-out allele die between E11 and E14. Mice heterozygous for the allele exhibit decreased PPI.

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All GO Annotations

30
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

785
Tissues

94
cDNA Data

151
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dars1

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All Sequences

61
RefSeq

4
UniProt

7
CCDS

CCDS15253.1, CCDS48348.1

Ensembl

ENSMUSG00000026356 (Evidence)
NCBI Gene

226414

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026356	Ensembl Gene Model \| MGI Sequence Detail	53662	C57BL/6J	± kb
transcript	ENSMUST00000027602	Ensembl \| MGI Sequence Detail	2175	Not Applicable
polypeptide	ENSMUSP00000027602	Ensembl \| MGI Sequence Detail	501	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000006281 aspartate--tRNA ligase, cytoplasmic

(term hierarchy)
EC

6.1.1.12
InterPro Domains

IPR006195 Aminoacyl-tRNA synthetase, class II

IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)

IPR004523 Aspartate-tRNA synthetase, type 2

IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb

IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

IPR012340 Nucleic acid-binding, OB-fold

IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
GlyGen

Q922B2 1 site, 1 O-linked glycan (1 site)

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All nucleic 152

cDNA 151

Primer pair 1

Microarray probesets 3

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MGI:7482289

Summaries

All 49

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 17
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32

TSS for Dars1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13458	Chr1:128345089-128345121 (-)	0 bp
Tssr13457	Chr1:128345053-128345087 (-)	35 bp
Tssr193	Chr1:128345031-128345042 (-)	68 bp
Tssr13456	Chr1:128345009-128345020 (-)	90 bp
Tssr13455	Chr1:128344972-128344983 (-)	127 bp
Tssr13454	Chr1:128344958-128344967 (-)	142 bp
Tssr13453	Chr1:128341760-128341765 (-)	3,342 bp
Tssr13452	Chr1:128332310-128332314 (-)	12,793 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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