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Dars1 Gene Detail
Summary
  • Symbol
    Dars1
  • Name
    aspartyl-tRNA synthetase 1
  • Synonyms
    5730439G15Rik, Dars
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442544
    NCBI Gene: 226414
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:128291444-128345105 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 55.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1295 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442544
 protein coding gene Chr1:128291444-128345153 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016430
 protein coding gene Chr1:131606211-131677134 (-)
A/J MGP_AJ_G0016413
 protein coding gene Chr1:126699383-126754630 (-)
AKR/J MGP_AKRJ_G0016378
 protein coding gene Chr1:130447256-130507629 (-)
BALB/cJ MGP_BALBcJ_G0016373
 protein coding gene Chr1:127075267-127141135 (-)
C3H/HeJ MGP_C3HHeJ_G0016199
 protein coding gene Chr1:130611379-130668039 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016834
 protein coding gene Chr1:136554662-136611717 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014547
 protein coding gene Chr1:120054683-120107255 (-)
CAST/EiJ MGP_CASTEiJ_G0015780
 protein coding gene Chr1:129597147-129654416 (-)
CBA/J MGP_CBAJ_G0016172
 protein coding gene Chr1:141160284-141220396 (-)
DBA/2J MGP_DBA2J_G0016278
 protein coding gene Chr1:125734384-125787737 (-)
FVB/NJ MGP_FVBNJ_G0016277
 protein coding gene Chr1:124451721-124505528 (-)
LP/J MGP_LPJ_G0016349
 protein coding gene Chr1:132956369-133010832 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016302
 protein coding gene Chr1:147001827-147060230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016870
 protein coding gene Chr1:130227689-130287530 (-)
PWK/PhJ MGP_PWKPhJ_G0015566
 protein coding gene Chr1:124712576-124768125 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015354
 protein coding gene Chr1:129180427-129242101 (-)
WSB/EiJ MGP_WSBEiJ_G0015842
 protein coding gene Chr1:130186522-130243277 (-)



Homology
more
  • Human Ortholog
    DARS1, aspartyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DARS1, aspartyl-tRNA synthetase 1
  • Synonyms
    aspRS, DARS, HBSL
  • Links
    NCBI Gene ID: 1615
    neXtProt AC: NX_P14868
    UniProt: P14868

  • Chr Location
    2q21.3; chr2:135905881-135986100 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die between E11 and E14. Mice heterozygous for the allele exhibit decreased PPI.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    94
  • cDNA Data
    151
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026356 Ensembl Gene Model | MGI Sequence Detail 53662 C57BL/6J ±  kb
transcript ENSMUST00000027602 Ensembl | MGI Sequence Detail 2175 Not Applicable  
polypeptide ENSMUSP00000027602 Ensembl | MGI Sequence Detail 501 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006281 aspartate--tRNA ligase, cytoplasmic
    (term hierarchy)
  • EC
    6.1.1.12
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
    IPR004523 Aspartate-tRNA synthetase, type 2
    IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
    IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
    IPR012340 Nucleic acid-binding, OB-fold
    IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
  • GlyGen
    Q922B2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 152
    cDNA 151
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:7482289
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory