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Pigv Gene Detail
Summary
  • Symbol
    Pigv
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class V
  • Synonyms
    D430024F16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442480
    NCBI Gene: 230801
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133387698-133399958 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442480
 protein coding gene Chr4:133387071-133401498 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028903
 protein coding gene Chr4:135950752-135962942 (-)
A/J MGP_AJ_G0028862
 protein coding gene Chr4:130243546-130255970 (-)
AKR/J MGP_AKRJ_G0028814
 protein coding gene Chr4:133947230-133959440 (-)
BALB/cJ MGP_BALBcJ_G0028885
 protein coding gene Chr4:130882999-130895645 (-)
C3H/HeJ MGP_C3HHeJ_G0028599
 protein coding gene Chr4:134202602-134214798 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029327
 protein coding gene Chr4:140821940-140834177 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026598
 protein coding gene Chr4:123307526-123319713 (-)
CAST/EiJ MGP_CASTEiJ_G0028032
 protein coding gene Chr4:132311979-132325709 (-)
CBA/J MGP_CBAJ_G0028564
 protein coding gene Chr4:144511634-144527098 (-)
DBA/2J MGP_DBA2J_G0028713
 protein coding gene Chr4:130665522-130677699 (-)
FVB/NJ MGP_FVBNJ_G0028681
 protein coding gene Chr4:129556733-129570460 (-)
LP/J MGP_LPJ_G0028814
 protein coding gene Chr4:136055076-136067364 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028706
 protein coding gene Chr4:149002940-149016069 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029365
 protein coding gene Chr4:134368083-134380343 (-)
PWK/PhJ MGP_PWKPhJ_G0027752
 protein coding gene Chr4:127382425-127394754 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027578
 protein coding gene Chr4:130203752-130216315 (-)
WSB/EiJ MGP_WSBEiJ_G0028111
 protein coding gene Chr4:134552422-134565610 (-)



Homology
more
  • Human Ortholog
    PIGV, phosphatidylinositol glycan anchor biosynthesis class V
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGV, phosphatidylinositol glycan anchor biosynthesis class V
  • Synonyms
    GPI-MT-II, HPMRS1, PIG-V
  • Links
    NCBI Gene ID: 55650
    neXtProt AC: NX_Q9NUD9
    UniProt: Q9NUD9

  • Chr Location
    1p36.11; chr1:26787963-26798403 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    20 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation exhibit complex congenital heart disease associated with heterotaxy, are runted, have thymus hypoplasia and show craniofacial and kidney defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    95
  • cDNA Data
    25
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043257 Ensembl Gene Model | MGI Sequence Detail 12261 C57BL/6J ±  kb
    transcript ENSMUST00000062118 Ensembl | MGI Sequence Detail 3979 Not Applicable  
    polypeptide ENSMUSP00000050647 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:299612 Rodriguez de Los Santos M, et al., A CRISPR-Cas9-engineered mouse model for GPI-anchor deficiency mirrors human phenotypes and exhibits hippocampal synaptic dysfunctions. Proc Natl Acad Sci U S A. 2021 Jan 12;118(2):e2014481118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    03/14/2023
    MGI 6.22     		The Jackson Laboratory