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Irf2bpl Gene Detail
Summary
  • Symbol
    Irf2bpl
  • Name
    interferon regulatory factor 2 binding protein-like
  • Synonyms
    6430527G18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442463
    NCBI Gene: 238330
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:86927475-86931572 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 41.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442463
protein coding gene Chr12:86927475-86931588 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0019931
protein coding gene Chr12:84423137-84427308 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0020362
protein coding gene Chr12:90279078-90287941 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017980
protein coding gene Chr12:81304982-81309086 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0019688
protein coding gene Chr12:93758587-93763037 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0019030
protein coding gene Chr12:78463267-78467296 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019319
protein coding gene Chr12:87076972-87080351 (-)



Homology
more
  • Human Ortholog
    IRF2BPL, interferon regulatory factor 2 binding protein like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF2BPL, interferon regulatory factor 2 binding protein like
  • Synonyms
    C14orf4, EAP1, NEDAMSS
  • Links
    NCBI Gene ID: 64207
    neXtProt AC: NX_Q9H1B7
    UniProt: Q9H1B7

  • Chr Location
    14q24.3; chr14:77024543-77028708 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human IRF2BPL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034168 Ensembl Gene Model | MGI Sequence Detail 4098 C57BL/6J ±  kb
    transcript ENSMUST00000038422 Ensembl | MGI Sequence Detail 4098 Not Applicable  
    polypeptide ENSMUSP00000041070 Ensembl | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006864 enhanced at puberty protein 1
    • EC
    • InterPro Domains
      IPR044882 Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily
      IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
    • GlyGen
      Q8K3X4 6 sites, 1 O-linked glycan (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 127

      Microarray probesets 8
    References
    more
    • Summaries
      All 34
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory