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Tspyl5 Gene Detail
Summary
  • Symbol
    Tspyl5
  • Name
    testis-specific protein, Y-encoded-like 5
  • Synonyms
    E130308C19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442458
    NCBI Gene: 239364
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:33684021-33688029 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 13.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442458
 protein coding gene Chr15:33684021-33688030 (-)
129S1/SvImJ ENSMUSG00200025499
 protein coding gene Chr15:30703790-30707805 (-)
A/J ENSMUSG00195035229
 protein coding gene Chr15:30604343-30608348 (-)
AKR/J ENSMUSG00220025875
 protein coding gene Chr15:30506692-30510701 (-)
BALB/cJ ENSMUSG00180030351
 protein coding gene Chr15:30560984-30564989 (-)
C3H/HeJ ENSMUSG00175025420
 protein coding gene Chr15:30747484-30751492 (-)
C57BL/6NJ ENSMUSG00215016385
 protein coding gene Chr15:30592084-30596093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019718
 protein coding gene Chr15:28673640-28677643 (-)
CAST/EiJ ENSTCUG00005010605
 protein coding gene Chr15:30605700-30609704 (-)
CBA/J ENSMUSG00210017764
 protein coding gene Chr15:30698133-30702142 (-)
DBA/2J ENSMUSG00185033432
 protein coding gene Chr15:30682850-30686859 (-)
FVB/NJ ENSMUSG00205027342
 protein coding gene Chr15:30567353-30571358 (-)
JF1/MsJ ENSUMUG00000028950
 protein coding gene Chr15:30622758-30626774 (-)
LP/J ENSMUSG00230011294
 protein coding gene Chr15:34100304-34104319 (-)
NOD/ShiLtJ ENSMUSG00190023624
 protein coding gene Chr15:30667632-30671647 (-)
NZO/HlLtJ ENSMUSG00225030627
 protein coding gene Chr15:34374404-34378413 (-)
PWK/PhJ ENSLUMG00010031066
 protein coding gene Chr15:30772333-30776348 (-)
SPRET/EiJ ENSMSPG00010012622
 protein coding gene Chr15:31362554-31364862 (-)
WSB/EiJ ENSIUOG00005031550
 protein coding gene Chr15:30697232-30701235 (-)



Homology
more
  • Human Ortholog
    TSPYL5, TSPY like 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPYL5, TSPY like 5
  • Links
    NCBI Gene ID: 85453
    UniProt: Q86VY4

  • Chr Location
    8q22.1; chr8:97273488-97277928 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males show reduced fertility with age, with reduced spermatogonia and sperm counts, reduced spermatogonia proliferation, and abnormal seminiferous tubule morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239364 NCBI Gene Model | MGI Sequence Detail 4009 C57BL/6J ±  kb
    transcript NM_001085421 RefSeq | MGI Sequence Detail 4040 C57BL/6  
    polypeptide Q69ZB3 UniProt | EBI | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 2
      cDNA 7

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:350814 Leng X, et al., Mouse Tspyl5 promotes spermatogonia proliferation through enhancing Pcna-mediated DNA replication. Reprod Fertil Dev. 2024 Jan;36
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory