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Cnot1 Gene Detail
Summary
  • Symbol
    Cnot1
  • Name
    CCR4-NOT transcription complex, subunit 1
  • Synonyms
    6030411K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442402
    NCBI Gene: 234594
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:96446079-96534092 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1570 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442402
 protein coding gene Chr8:96445559-96534741 (-)
129S1/SvImJ ENSMUSG00200014549
 protein coding gene Chr8:90808248-90877665 (-)
A/J ENSMUSG00195003764
 protein coding gene Chr8:91143107-91212533 (-)
AKR/J ENSMUSG00220011057
 protein coding gene Chr8:91179945-91249366 (-)
BALB/cJ ENSMUSG00180003774
 protein coding gene Chr8:91045190-91114613 (-)
C3H/HeJ ENSMUSG00175002559
 protein coding gene Chr8:91087540-91156971 (-)
C57BL/6NJ ENSMUSG00215001225
 protein coding gene Chr8:90718337-90787795 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031430
 protein coding gene Chr8:87199408-87287924 (-)
CAST/EiJ ENSTCUG00005016952
 protein coding gene Chr8:90543263-90612751 (-)
CBA/J ENSMUSG00210014858
 protein coding gene Chr8:91022983-91092406 (-)
DBA/2J ENSMUSG00185021933
 protein coding gene Chr8:97131846-97201266 (-)
FVB/NJ ENSMUSG00205016409
 protein coding gene Chr8:90132634-90202053 (-)
JF1/MsJ ENSUMUG00000036733
 protein coding gene Chr8:99499533-99568951 (-)
LP/J ENSMUSG00230006145
 protein coding gene Chr8:100793225-100862675 (-)
NOD/ShiLtJ ENSMUSG00190011781
 protein coding gene Chr8:91148794-91218214 (-)
NZO/HlLtJ ENSMUSG00225009716
 protein coding gene Chr8:104198200-104267620 (-)
PWK/PhJ ENSLUMG00010039289
 protein coding gene Chr8:90871643-90941256 (-)
SPRET/EiJ ENSMSPG00010005657
 protein coding gene Chr8:92894330-92962630 (-)
WSB/EiJ ENSIUOG00005005483
 protein coding gene Chr8:91857300-91926411 (-)



Homology
more
  • Human Ortholog
    CNOT1, CCR4-NOT transcription complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT1, CCR4-NOT transcription complex subunit 1
  • Synonyms
    AD-005, CDC39, HPE12, NOT1, NOT1H, VIBOS
  • Links
    NCBI Gene ID: 23019
    UniProt: A5YKK6

  • Chr Location
    16q21; chr16:58519951-58629885 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CNOT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hmozygous for a conditional allele activated in cardiomyocytes exhibit postnatal lethality, decreased cardiac muscle contractility, prolonged QT interval and cardiac muscle cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    151
  • cDNA Data
    283
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036550 Ensembl Gene Model | MGI Sequence Detail 88014 C57BL/6J ±  kb
    transcript ENSMUST00000098473 Ensembl | MGI Sequence Detail 8390 Not Applicable  
    polypeptide ENSMUSP00000096073 Ensembl | MGI Sequence Detail 2376 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000005648 CCR4-NOT transcription complex subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR007196 CCR4-Not complex component, Not1, C-terminal
      IPR038535 CCR4-NOT subunit 1, TTP binding domain superfamily
      IPR040398 CCR4-NOT transcription complex subunit 1
      IPR032191 CCR4-NOT transcription complex subunit 1, CAF1-binding domain
      IPR024557 CCR4-NOT transcription complex subunit 1, domain 4
      IPR032194 CCR4-NOT transcription complex subunit 1, HEAT repeat
      IPR055454 CCR4-NOT transcription complex subunit 1-like, NOT1 connector
      IPR055104 CCR4-NOT transcription complex subunit 1, N-terminal domain
      IPR032193 CCR4-NOT transcription complex subunit 1, TTP binding domain
    • GlyGen
      Q6ZQ08 16 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (13 sites)
    Molecular
    Reagents
    less
    • All nucleic 285
      cDNA 283
      Primer pair 1
      Other 1
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:3034660
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:361793 Serdar LD, et al., mRNA stability fine-tunes gene expression in the developing cortex to control neurogenesis. PLoS Biol. 2025 Feb;23(2):e3003031
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory