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Slc13a4 Gene Detail
Summary
  • Symbol
    Slc13a4
  • Name
    solute carrier family 13 (sodium/sulfate symporters), member 4
  • Synonyms
    9630060C05Rik, SUT1, SUT-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442367
    NCBI Gene: 243755
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:35244888-35285061 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442367
 protein coding gene Chr6:35244888-35285066 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030570
 protein coding gene Chr6:33413714-33459633 (-)
A/J MGP_AJ_G0030543
 protein coding gene Chr6:31963180-32003369 (-)
AKR/J MGP_AKRJ_G0030470
 protein coding gene Chr6:33036614-33080434 (-)
BALB/cJ MGP_BALBcJ_G0030553
 protein coding gene Chr6:32153096-32193291 (-)
C3H/HeJ MGP_C3HHeJ_G0030266
 protein coding gene Chr6:33007774-33048631 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031007
 protein coding gene Chr6:34234502-34277526 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028219
 protein coding gene Chr6:30047340-30088007 (-)
CAST/EiJ MGP_CASTEiJ_G0029668
 protein coding gene Chr6:32848930-32892914 (-)
CBA/J MGP_CBAJ_G0030244
 protein coding gene Chr6:35585128-35628331 (-)
DBA/2J MGP_DBA2J_G0030388
 protein coding gene Chr6:31838874-31879080 (-)
FVB/NJ MGP_FVBNJ_G0030342
 protein coding gene Chr6:31637661-31679097 (-)
LP/J MGP_LPJ_G0030475
 protein coding gene Chr6:33513810-33557340 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030378
 protein coding gene Chr6:37873527-37915106 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031037
 protein coding gene Chr6:32920021-32960699 (-)
PWK/PhJ MGP_PWKPhJ_G0029382
 protein coding gene Chr6:31477848-31518388 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029218
 protein coding gene Chr6:32609374-32658622 (-)
WSB/EiJ MGP_WSBEiJ_G0029744
 protein coding gene Chr6:32868630-32910915 (-)



Homology
more
  • Human Ortholog
    SLC13A4, solute carrier family 13 member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC13A4, solute carrier family 13 member 4
  • Synonyms
    NAS2, SUT1, SUT-1
  • Links
    NCBI Gene ID: 26266
    neXtProt AC: NX_Q9UKG4
    UniProt: Q9UKG4

  • Chr Location
    7q33; chr7:135681231-135729258 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display lethality before birth, impaired placental sulfate transport, failure of bone ossification, impaired vascular development, hemorrhaging, and cleft palate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    6
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 243755 NCBI Gene Model | MGI Sequence Detail 40174 C57BL/6J ±  kb
    transcript NM_172892 RefSeq | MGI Sequence Detail 3426 C57BL/6  
    polypeptide NP_766480 RefSeq | MGI Sequence Detail 625 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001898 Solute carrier family 13
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:307657 Sharmin S, et al., Perineuronal net abnormalities in Slc13a4(+/-) mice are rescued by postnatal administration of N-acetylcysteine. Exp Neurol. 2021 Aug;342:113734
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory