Lingo2 MGI Mouse Gene Detail - MGI:2442298 - leucine rich repeat and Ig domain containing 2

Symbol

Lingo2
Name

leucine rich repeat and Ig domain containing 2
Synonyms

B230217C06Rik, LERN3, Lrrn6c

Feature Type

protein coding gene
IDs

MGI:2442298
NCBI Gene: 242384
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:35706647-36951747 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 17.74 cM
Mapping Data

2 experiments

SNPs within 2kb

6312 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442298	protein coding gene	Chr4:35696778-36951929 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028138	protein coding gene	Chr4:33353585-34657507 (-)
A/J	MGP_AJ_G0028096	protein coding gene	Chr4:32112449-33371175 (-)
AKR/J	MGP_AKRJ_G0028059	protein coding gene	Chr4:32973506-34254096 (-)
BALB/cJ	MGP_BALBcJ_G0028108	protein coding gene	Chr4:32389726-33685817 (-)
C3H/HeJ	MGP_C3HHeJ_G0027836	protein coding gene	Chr4:33289227-34602434 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028549	protein coding gene	Chr4:34595966-35997562 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025890	protein coding gene	Chr4:30147798-31309567 (-)
CAST/EiJ	MGP_CASTEiJ_G0027292	protein coding gene	Chr4:33080875-34402301 (-)
CBA/J	MGP_CBAJ_G0027808	protein coding gene	Chr4:35722038-37165958 (-)
DBA/2J	MGP_DBA2J_G0027952	protein coding gene	Chr4:32071805-33316768 (-)
FVB/NJ	MGP_FVBNJ_G0027919	protein coding gene	Chr4:31495277-32731774 (-)
LP/J	MGP_LPJ_G0028060	protein coding gene	Chr4:33437637-34731233 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027952	protein coding gene	Chr4:38379740-39991100 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028608	protein coding gene	Chr4:33012819-34343041 (-)
PWK/PhJ	MGP_PWKPhJ_G0027010	protein coding gene	Chr4:32119834-33364616 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026839	protein coding gene	Chr4:32870222-34135887 (-)
WSB/EiJ	MGP_WSBEiJ_G0027368	protein coding gene	Chr4:33002369-34319492 (-)

Human Ortholog

LINGO2, leucine rich repeat and Ig domain containing 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LINGO2, leucine rich repeat and Ig domain containing 2
Synonyms

LERN3, LRRN6C
Links

HGNC:21207

NCBI Gene ID: 158038

neXtProt AC: NX_Q7L985

UniProt: Q7L985
Chr Location

9p21.2-p21.1; chr9:27937617-29213601 (-) GRCh38

MGI Vertebrate Homology

Lingo2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LINGO2
Gene Tree

Lingo2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically and radiation induced

1
Endonuclease-mediated

3
Targeted

1
Genomic Mutations

1 involving Lingo2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

32
cDNA Data

16
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lingo2

ZFIN si:ch211-170a17.1

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All Sequences

107
RefSeq

53
UniProt

4
CCDS

CCDS18040.1

Ensembl

ENSMUSG00000045083 (Evidence)
NCBI Gene

242384

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045083	Ensembl Gene Model \| MGI Sequence Detail	1245101	C57BL/6J	± kb
transcript	ENSMUST00000098151	Ensembl \| MGI Sequence Detail	2781	Not Applicable
polypeptide	ENSMUSP00000095754	Ensembl \| MGI Sequence Detail	606	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030365 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

(term hierarchy)
InterPro Domains

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype

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All nucleic 20

cDNA 16

Primer pair 3

Other 1

Microarray probesets 5

Summaries

All 33

Developmental Gene Expression 6

Gene Ontology 3

Phenotypes 6
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:279471 Belle NM, et al., TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths. Nat Commun. 2019 Sep 27;10(1):4408

TSS for Lingo2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr41229	Chr4:36951689-36951759 (-)	23 bp
Tssr41228	Chr4:36936311-36936315 (-)	15,434 bp
Tssr41227	Chr4:36856502-36856506 (-)	95,243 bp
Tssr41226	Chr4:36664950-36664953 (-)	286,795 bp
Tssr41225	Chr4:36654162-36654165 (-)	297,583 bp
Tssr41224	Chr4:36321165-36321170 (-)	630,579 bp
Tssr41222	Chr4:35795200-35795204 (-)	1,156,545 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23