Rab7b MGI Mouse Gene Detail - MGI:2442295 - RAB7B, member RAS oncogene family

Symbol

Rab7b
Name

RAB7B, member RAS oncogene family
Synonyms

5430435G22Rik, Rab7b

Feature Type

protein coding gene
IDs

MGI:2442295
NCBI Gene: 226421
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:131616433-131643177 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 57.18 cM
Mapping Data

1 experiment

SNPs within 2kb

875 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442295	protein coding gene	Chr1:131616412-131646288 (+)
129S1/SvImJ	ENSMUSG00200006678	protein coding gene	Chr1:129171125-129198047 (+)
A/J	ENSMUSG00195040219	protein coding gene	Chr1:128278908-128305659 (+)
AKR/J	ENSMUSG00220045519	protein coding gene	Chr1:128109482-128136402 (+)
BALB/cJ	ENSMUSG00180034652	protein coding gene	Chr1:128825430-128852161 (+)
C3H/HeJ	ENSMUSG00175035471	protein coding gene	Chr1:128523609-128550354 (+)
C57BL/6NJ	ENSMUSG00215043312	protein coding gene	Chr1:128539293-128566036 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014575	protein coding gene	Chr1:123254791-123282021 (+)
CAST/EiJ	ENSTCUG00005028456	protein coding gene	Chr1:127444243-127470899 (+)
CBA/J	ENSMUSG00210026223	protein coding gene	Chr1:128419888-128446820 (+)
DBA/2J	ENSMUSG00185027971	protein coding gene	Chr1:132769979-132796900 (+)
FVB/NJ	ENSMUSG00205034588	protein coding gene	Chr1:127756624-127783357 (+)
JF1/MsJ	ENSUMUG00000038159	protein coding gene	Chr1:131938591-131965443 (+)
LP/J	ENSMUSG00230035042	protein coding gene	Chr1:132364396-132391141 (+)
NOD/ShiLtJ	ENSMUSG00190025817	protein coding gene	Chr1:128433484-128460231 (+)
NZO/HlLtJ	ENSMUSG00225017264	protein coding gene	Chr1:136085769-136112501 (+)
PWK/PhJ	ENSLUMG00010027463	protein coding gene	Chr1:127544513-127571122 (+)
SPRET/EiJ	ENSMSPG00010041721	protein coding gene	Chr1:130359361-130382439 (+)
WSB/EiJ	ENSIUOG00005042914	protein coding gene	Chr1:128166617-128193532 (+)

Human Ortholog

RAB7B, RAB7B, member RAS oncogene family

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB7B, RAB7B, member RAS oncogene family
Synonyms

RAB7
Links

HGNC:30513

NCBI Gene ID: 338382

UniProt: Q96AH8
Chr Location

1q32.1; chr1:205976740-206003461 (-) GRCh38

MGI Vertebrate Homology

Rab7b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: RAB7B
Gene Tree

Rab7b

less

Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Rab7b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

Mice homozygous for a null allele exhibit impaired dendritic cell migration with reduced number of small lysosomes per cell in LPS-exposed cells.

less

All GO Annotations

47
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab7b

less

All Sequences

65
RefSeq

20
UniProt

4
CCDS

CCDS15272.1, CCDS78677.1

Ensembl

ENSMUSG00000052688 (Evidence)
NCBI Gene

226421

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052688	Ensembl Gene Model \| MGI Sequence Detail	26745	C57BL/6J	± kb
transcript	ENSMUST00000064679	Ensembl \| MGI Sequence Detail	4498	Not Applicable
polypeptide	ENSMUSP00000065456	Ensembl \| MGI Sequence Detail	199	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000013640 Ras-related protein Rab-7b

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR005225 Small GTP-binding domain

less

All nucleic 6

cDNA 6

Microarray probesets 4

Summaries

All 38

Gene Ontology 10

Phenotypes 7
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:321707 Vestre K, et al., Rab7b regulates dendritic cell migration by linking lysosomes to the actomyosin cytoskeleton. J Cell Sci. 2021 Sep 15;134(18):jcs259221

TSS for Rab7b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8651	Chr1:131616408-131616472 (+)	7 bp
Tssr8652	Chr1:131616482-131616491 (+)	54 bp
Tssr8653	Chr1:131616509-131616522 (+)	83 bp
Tssr8654	Chr1:131624356-131624368 (+)	7,929 bp
Tssr8655	Chr1:131624395-131624406 (+)	7,968 bp
Tssr8656	Chr1:131640358-131640370 (+)	23,931 bp
Tssr8657	Chr1:131640453-131640463 (+)	24,025 bp
Tssr8658	Chr1:131640656-131640667 (+)	24,229 bp
Tssr8659	Chr1:131640834-131640849 (+)	24,409 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24